Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Sharifi-Rad J. Quispe C. Mukazhanova Z. Knut E. Turgumbayeva A. Kipchakbayeva A. Seitimova G. Mahomoodally M.F. Lobine D. Koay A. Wang J. Sheridan H. Leyva-Gómez G. Prado-Audelo M.L.D. Cortes H. Rescigno A. Zucca P. Sytar O. Imran M. Rodrigues C.F. Cruz-Martins N. Ekiert H. Kumar M. Abdull Razis A.F. Sunusi U. Kamal R.M. Szopa A.
1 September 2021Frontiers Media S.A.
Frontiers in Molecular Biosciences
2021#8
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. © Copyright
bio-availability , cancer therapy , clinical applications , drug-delivery systems , resveratrol
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Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile
Department of Natural Sciences and Technologies, Sarsen Amanzholov East Kazakhstan State University, Ust-Kamenogorsk, Kazakhstan
Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland
Asfendiyarov Kazakh National Medical University, School Pharmacy, Almaty, Kazakhstan
Al-Farabi Kazakh National University, Higher School of Medicine, Almaty, Kazakhstan
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
Trinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico
Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico City, Mexico
Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy
Department of Plant Biology, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Department of Plant Physiology, Slovak University of Agriculture, Nitra, Slovakia
University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal
Chemical and Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai, India
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Department of Biochemistry, Bayero University Kano, Kano, Nigeria
Department of Pharmacology, Federal University Dutse, Dutse, Nigeria
Phytochemistry Research Center
Facultad de Ciencias de la Salud
Department of Natural Sciences and Technologies
Chair and Department of Pharmaceutical Botany
Asfendiyarov Kazakh National Medical University
Al-Farabi Kazakh National University
Faculty of Chemistry and Chemical Technology
Department of Health Sciences
Trinity College Dublin
Departamento de Farmacia
Laboratorio de Medicina Genómica
Department of Biomedical Sciences
Department of Plant Biology
Department of Plant Physiology
University Institute of Diet and Nutritional Sciences
Laboratory for Process Engineering
Faculty of Medicine
Institute for Research and Innovation in Health (i3S)
Laboratory of Neuropsychophysiology
Chemical and Biochemical Processing Division
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Pharmacology
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