Metabolomic-based promising technique for fruit-based natural products analysis
Rauf A. Olatunde A. Akram Z. Hemeg H.A. Khalil A.A. Shariati M.A. Edis Z. Thiruvengadam M. Kim S.-H.
December 2025Elsevier Ltd
Food Chemistry: X
2025#32
Fruit-based natural products have significant health and commercial benefits. Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is a powerful technique to profile complex chemical compositions. This review focuses on the use of LC-HRMS for profiling fruit-derived bioactive chemicals and demonstrates the advantages of LC for separation and HRMS for precise mass detection. LC-HRMS enables the detection of a wide range of bioactive compounds, while providing excellent precision and resolution, allowing distinction between isomeric and isobaric compounds and advancing the understanding of fruit metabolomes and their roles in food and pharmaceutical sciences. Although challenges such as complex sample preparation and limited databases persist, LC-HRMS continues to be the leading method for discovering novel bioactive compounds. Continuous improvements in analytical procedures and data resources are required to fully realize the potential of LC-HRMS. Overall, the integration of LC and HRMS has altered fruit-based analyses of natural products, providing their chemical profiles and encouraging innovations in health-related and industrial applications.
Bioactives , Chemical profiling , Liquid chromatography-High resolution mass spectrometry , Natural products
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Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Swabi, 94640, Pakistan
Department of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi, 740272, Nigeria
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, 75340, Pakistan
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia
University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, 54000, Pakistan
Kazakh Research Institute of Processing and Food Industry, Semey Branch of the Institute, 238«G» Gagarin Ave, Almaty, 050060, Kazakhstan
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, United Arab Emirates
Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, South Korea
Department of Chemistry
Department of Medical Biochemistry
Department of Pharmacology
Department of Clinical Laboratory Sciences
University Institute of Diet and Nutritional Sciences
Kazakh Research Institute of Processing and Food Industry
Center of Medical and Bio-Allied Health Sciences Research
Department of Crop Science
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