Role of Phytonutrients in the Prevention and Treatment of Chronic Diseases: A Concrete Review
Tufail T. Fatima S. Bader Ul Ain H. Ikram A. Noreen S. Rebezov M. AL-Farga A. Saleh R. Shariati M.A.
8 April 2025American Chemical Society
ACS Omega
2025#10Issue 1312724 - 12755 pp.
Delving into the intricate role of phytonutrients is paramount to effectively preventing and treating chronic diseases. Phytonutrients are “plant-based nutrients” that positively affect human health. Phytonutrients perform primary therapeutic functions in the management and treatment of various diseases. It is reported that different types of pathogenesis occur due to the excessive production of oxidants (reactive nitrogen species and reactive oxygen species). The literature shows that a higher intake of fruits, vegetables, and other plant-based food is inversely related to treating different chronic diseases. Due to many phytonutrients (antioxidants) in fruits, vegetables, and other medicinal plants, they are considered major therapeutic agents for various diseases. The main purpose of this review is to summarize the major phytonutrients involved in preventing and treating diseases. Fourteen major phytonutrients are discussed in this review, such as polyphenols, anthocyanin, resveratrol, phytosterol (stigmasterol), flavonoids, isoflavonoids, limonoids, terpenoids, carotenoids, lycopene, quercetin, phytoestrogens, glucosinolates, and probiotics, which are well-known for their beneficial effects on the human body and treatment of different pathological conditions. It is concluded that phytonutrients play a major role in the prevention and treatment of diabetes mellitus, obesity, hypertension, cardiovascular disorders, other types of cancers, neurological disorders, age-related diseases, and inflammatory disorders and are also involved in various biological activities.
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School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China
University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, 54000, Pakistan
Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str., Moscow, 109316, Russian Federation
Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht str., Yekaterinburg, 620075, Russian Federation
Department of Biotechnology, Toraighyrov University, 64 Lomov Str., Pavlodar, 140008, Kazakhstan
Department of Biochemistry, College of Sciences, University of Jeddah, Jeddah, 21577, Saudi Arabia
Medical Microbiology Department, Faculty of Science, IBB University, IBB, Yemen
Kazakh Research Institute of Processing and Food Industry (Semey Branch), Semey, 071410, Kazakhstan
School of Food and Biological Engineering
University Institute of Diet and Nutritional Sciences
Department of Scientific Research
Faculty of Biotechnology and Food Engineering
Department of Biotechnology
Department of Biochemistry
Medical Microbiology Department
Kazakh Research Institute of Processing and Food Industry (Semey Branch)
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