Sustainable and smart nano-biosensors: Integrated solutions for healthcare, environmental monitoring, agriculture, and food safety
Thiruvengadam M. Chi H.-Y. Choi H.-J. Jung B.-S. Lee S.-B. Park Y. Jeon D. Ciftci F. Shariati M.A. Kim S.-H.
1 October 2025Elsevier B.V.
Industrial Crops and Products
2025#233
The demand for highly sensitive and specific biosensors is growing rapidly across multiple sectors, including medical diagnostics, environmental monitoring, pathogen detection, and food safety. This review critically explores the advancements in nano-enabled biosensor technologies, focusing on bio-based nanosensors synthesized using plant-derived phytochemicals, cellulose, and lignin. These naturally derived materials serve as eco-friendly stabilizing and reducing agents for the formation of functional nanoparticles (NPs). This review (i) discusses the synthesis and characterization techniques of bio-nanosensors; (ii) examines their physical, chemical, and biological interactions; and (iii) evaluates their applications in early disease screening, diagnostics (e.g., cancer and diabetes), and the detection of pathogens, pollutants, and toxins. In addition, we address key challenges associated with bio-based nanomaterials, including NP toxicity, biocompatibility, and the need for appropriate regulatory frameworks. Furthermore, we highlight the growing role of artificial intelligence, machine learning, and the Internet of Things in enhancing biosensor performance and commercialization. This review concludes by emphasizing the potential of bio-based nanosensors for clinical, environmental, and food safety applications, while advocating the development of micro- and disposable sensor formats. By highlighting the potential and limitations of bionanosensors, this review provides a foundation for future research and the development of clinical and commercial applications.
Biosensors , Diagnostics , Environmental monitoring , Food safety , Nanotechnology , Phytochemicals
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Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, South Korea
Department of Biomedical Engineering, Faculty of Engineering, Fatih Sultan Mehmet Vakıf University, Istanbul, 34015, Turkey
Kazakh Research Institute of Processing and Food Industry, Semey Branch of the Institute, 238«G» Gagarin Ave, Almaty, 050060, Kazakhstan
Department of Crop Science
Department of Biomedical Engineering
Kazakh Research Institute of Processing and Food Industry
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026