Isolation of Novel Compounds from Lepidium sativum Seeds and Evaluation of Their Potential Anti-Tumor Activity
Shybyray Y. Kaiyrkulova A. Zhao H.-Q. Jenis J. Aisa H.A. Li J.
January 2025John Wiley and Sons Inc
Chemistry and Biodiversity
2025#22Issue 1
Four undescribed compounds including a pair of enantiomers of a dihydroarylnaphthalene lignan [(±)−1], an arylnaphthalene lignan (2), and an indoleacetic acid ester (3), together with four known compounds (4–7), were isolated from the seeds of Lepidium sativum. Their structures were identified by HRMS and NMR spectroscopic data, and the absolute configuration of these compounds were assigned by ECD data in combination with quantum chemical calculations. Compound (−)−1 had weak inhibitory activity against HeLa cell line with an IC50 value of 60.23±3.51 μM, and compound (+)−1 presented moderate inhibitory effect against HeLa cell line with an IC50 value of 19.99±1.00 μM (IC50 value of the positive control was 0.40±0.02 μM).
Anti-tumor , ECD calculations , Indoleacetic acid ester , Lepidium sativum , Lignan
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State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi, Xinjiang, 830011, China
University of Chinese Academy of Sciences, Beijing, 100039, China
The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty, 050040, Kazakhstan
Research Institute for Natural Products & Technology, Almaty, 050046, Kazakhstan
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone
University of Chinese Academy of Sciences
The Research Center for Medicinal Plants
Research Institute for Natural Products & Technology
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