Therapeutic potential of herbal medicine for the management of hyperlipidemia: latest updates
Rauf A. Akram M. Anwar H. Daniyal M. Munir N. Bawazeer S. Bawazeer S. Rebezov M. Bouyahya A. Shariati M.A. Thiruvengadam M. Sarsembenova O. Mabkhot Y.N. Islam M.N. Emran T.B. Hodak S. Zengin G. Khan H.
June 2022Springer Science and Business Media Deutschland GmbH
Environmental Science and Pollution Research
2022#29Issue 2740281 - 40301 pp.
Hyperlipidemia, the most common form of dyslipidemia, is the main source of cardiovascular disorders, characterized by elevated level of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) with high-density lipoprotein cholesterol (HDL-C) in peripheral blood. It is caused by a defect in lipid metabolism in the surface of Apoprotein C-II or a defect in lipoprotein lipase activity as well as reported in genetic, dietary and environmental factors. Several electronic databases were investigated as information sources, including Google Scholar, PubMed, Web of Science, Scopus, ScienceDirect, SpringerLink, Semantic Scholar, MEDLINE and CNKI Scholar. The current review focused on the risk factors of dyslipidemia, synthetic medication with their side effects and different types of medicinal plants having significant potential for the management of hyperlipidemia. The management of hyperlipidemia mostly involves a constant decrease in lipid level using different remedial drugs like statin, fibrate, bile acid sequestrates and niacin. However, this extensive review suggested that the consequences of these drugs are arguable, due to their numerous adverse effects. The selected parts of herb plants are used intact or their extracts containing active phytoconstituents to regulate the lipids in blood level. It was also noted that the Chinese herbal medicine and combination therapy is promising for the lowering of hyperlipidemia. This review intends to provide a scientific base for future endeavors, such as in-depth biological and chemical investigations into previously researched topics.
Cardiovascular disorders , Herbal medicine , Herbs medicinal plants , Hyperlipidemia , Lipid lowering drugs , Lipids
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Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Anbar, 23430, Pakistan
Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan
TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China
Department of Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, P.O. Box 42, Makkah, Saudi Arabia
V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation
Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russian Federation
K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), Moscow, Russian Federation
Laboratory of Human Pathology Biology, Faculty of Sciences, and Genomic Center of Human Pathology, Mohammed V University, Rabat, Morocco
Department of Applied Bioscience, Konkuk University, Seoul, South Korea
Eurasian Technological University, Almaty, Kazakhstan
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, 61421, Saudi Arabia
Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh
Department of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan
Department of Chemistry
Department of Eastern Medicine
TCM and Ethnomedicine Innovation and Development International Laboratory
Department of Biochemistry
Department of Pharmaceutical Chemistry
V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences
Prokhorov General Physics Institute
K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University)
Laboratory of Human Pathology Biology
Department of Applied Bioscience
Eurasian Technological University
Department of Pharmaceutical Chemistry
Department of Pharmacy
Department of Pharmacy
Department of Biology
Department of Pharmacy
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