Preparation of encapsulated α-tocopherol acetate and study of its physico-chemical and biological properties
Қапталған α-токоферол ацетатының алынуы және оның физикалық-химиялық пен биологиялық қасиеттерін зерттеу
Получение инкапсулированного ацетата α-токоферола и исследование его физико-химических и биологических свойств
Mustafayeva A. Iskineyeva A. Zamaratskaya G. Fazylov S. Pustolaikina A.I. Nurkenov A.O. Sarsenbekova A. Seilkhanov T. Bakirova R.
2021E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2021#103Issue 327 - 36 pp.
The article discusses the results of research for obtaining encapsulated vitamin E using a water-soluble oligosaccharide (cyclodextrin). The inclusion complexes of β-CD with α-tocopherol were obtained in an aqueous-alcoholic medium by coprecipitation and microwave activation. The highest yields of target clathrate inclusion complexes of vitamin E with cyclodextrin were obtained under microwave synthesis conditions. Molecular modeling of inclusion complexes of α-tocopherol acetate with β-cyclodextrin in the ratios of 1:1, 1:2, 1:3, and 1:4 was performed using the MM+ method. Based on semi-empirical PM3 calculations, without taking into account the influence of the environment, the total energy of the systems under study was estimated. Data on the study of the structure of the clathrate complex of α-tocopherol acetate with β-cyclodextrin was presented. The surface morphology of the resulting “guest-host” clathrate complex was described using a scanning electron microscope. The spectral properties of the inclusion complex were characterized by FT-IR and 1H and 13C NMR spectroscopy data. The study of the 1H NMR and 13C NMR spectra of β-CD in the free and bound state in the form of the β-CD: VE clathrate made it possible to reveal the displacements of the signals of the nuclei (± ∆δ) 1H and 13C of the host molecule both in the region of weak and strong fields. The experimental results confirmed the possibility of the formation of inclusion complexes of α-tocopherol acetate with β-cyclodextrin at various ratios. The data on the study of the effect of encapsulated α-tocopherol acetate on the safety of food meat products was presented.
Clathrate , Cyclodextrin , Inclusion complexes , NMR spectroscopy , Oligosaccharides , Starch , Vitamin E , α-tocopherol acetate
Text of the article Перейти на текст статьи
S. Seifullin Kazakh Agrotechnical University, Nur-Sultan, Kazakhstan
Department of Molecular Sciences, BioCenter, Swedish University of Agricultural Sciences, Up sala, Sweden
Karagandy University of the name of academician E.A. Buketov, Universitetskaya street, 28, Karaganda, 100028, Kazakhstan
Sh. Ualikhanov Kokshetau University, Kokshetau, Kazakhstan
Karaganda Medical University, Kazakhstan
S. Seifullin Kazakh Agrotechnical University
Department of Molecular Sciences
Karagandy University of the name of academician E.A. Buketov
Sh. Ualikhanov Kokshetau University
Karaganda Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026