UTILIZATION OF MICROWAVE ASSISTED EXTRACTS OBTAINED FROM VARIOUS PARTS (WHOLE FRUIT, SEEDS, LEAVES AND ROOTS) OF CITRULLUS COLOCYNTHIS AS HYPOCHOLESTEROLEMIC AGENT IN ALBINO RATS
Khalil A.A. Shahid Q.A. Aslam A. Khalid A. Hlebová M. Rebezov M. Peshcherov G. Okuskhanova E. Shariati M.A.
2021Slovak University of Agriculture
Journal of Microbiology, Biotechnology and Food Sciences
2021#10Issue 4541 - 545 pp.
The study was conducted to investigate the hypolipidemic properties of Microwave assisted extracts (MAE) obtained from different parts (whole fruit, leaves, seeds and roots) of Citrullus colocynthis on hyperlipidemic experimental rats. The trial consisted of 30 male rats that were divided into six groups each having 5 rats whereas, out of these 25 were hyperlipidemic and 5 were normal rats. After the induction of high cholesterol for 15 days, 20 rats were fed with microwave assisted extract of different parts at a concentration of 200mg/kg/B. W for 28 days. The administration of the extracts reported considerable reduction in the lipid profile parameters of the hypercholesterolemic rats. The MAE of seed of Citrullus colocynthis displayed the optimum results showing reduced levels of cholesterol, triglyceride and LDL-c by (10.33%), (22.50%) and (15.70%) while an elevation of (16.75%) in HDL-c content compared to the hypercholesterolemic control. Likewise, the percent increase in the concentrations of CAT and SOD by (6.92%) and (18.47%). The study concluded that the MAE of Citrullus colocynthis showed a positive effect on hypercholesterolemia thus providing therapeutic benefits.
Cholesterol , Citrullus colocynthis , Hyperlipidemia , Microwave Assisted Extracts
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University of Lahore, Faculty of Allied Health Sciences, University Institute of Diet and Nutritional Sciences, 1-km Defense road, near Bhuptian chowk, Lahore, Punjab, Pakistan
University of SS. Cyril and Methodius, Department of Biology, Faculty of Natural Sciences, Nám. J. Herdu 2, Trnava, SK-91701, Slovakia
V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation
Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russian Federation
Russian state agrarian correspondence university, Balashikha, Russian Federation
Research Institute of the Federal Penitentiary Service of Russia, Russian Federation
Shakarim State University of Semey, Semey, Kazakhstan
University of Lahore
University of SS. Cyril and Methodius
V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences
Prokhorov General Physics Institute
Russian state agrarian correspondence university
Research Institute of the Federal Penitentiary Service of Russia
Shakarim State University of Semey
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