Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng.
Kazymbetova A. Amangeldi M. Nurlybekova A. Amzeyeva U. Baktybala K. Tang C.-P. Ke C.-Q. Yao S. Ye Y. Jenis J.
November 2022MDPI
Molecules
2022#27Issue 22
As a promising source of biologically active substances, the Artemisia species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the Artemisia plants, systematic investigations of two Artemisia species growing in the East Kazakhstan region were conducted. In this study, one new germacrane-type sesquiterpene lactone (11), together with 10 known sesquiterpenes and its dimer, were characterized from A. nitrosa Weber. Additionally, one new chromene derivative (1’) with another 12 known compounds, including coumarins, sesquiterpene diketones, phenyl propanoids, polyacetylenics, dihydroxycinnamic acid derivatives, fatty acids, naphthalene derivatives, flavones, and caffeic acid derivatives were isolated from A. marschalliana Spreng. All compounds were isolated and identified for the first time from these two Artemisia species. The structures of new compounds (11, 1’) were established by using UV, TOFMS, LC–MS, 1D and 2D NMR spectroscopic analyses. The cytotoxicity of all isolated compounds was evaluated. As a result, all compounds did not show significant inhibition against HL-60 and A-549 cell lines. The sesquiterpenoids isolated from A. nitrosa were tested for their inhibitory activity against the LPS-induced NO release from the RAW624.7 cells, and neither of them exhibited significant activity.
A-549 , Artemisia marschalliana , Artemisia nitrosa , coumarin , cytotoxicity , flavonoid , HL-60 , phenolic compound , sesquiterpene lactone
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The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty, 050040, Kazakhstan
University of Chinese Academy of Sciences, Beijing, 100049, China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
Research Institute for Natural Products & Technology, Almaty, 050046, Kazakhstan
The Research Center for Medicinal Plants
University of Chinese Academy of Sciences
State Key Laboratory of Drug Research
Research Institute for Natural Products & Technology
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