Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations
Butnariu M. Quispe C. Koirala N. Khadka S. Salgado-Castillo C.M. Akram M. Anum R. Yeskaliyeva B. Cruz-Martins N. Kumar M.M.M. Bagiu R.V. Razis A.F.A. Sunusi U. Kamal R.M. Sharifi-Rad J.
2022Dove Medical Press Ltd
International Journal of Nanomedicine
2022#173619 - 3632 pp.
Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available.
bioactivities , curcumin , HIV therapy , nanoformulations , nanoparticles
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Chemistry & Biochemistry Discipline, University of Life Sciences “King Mihai I” from Timisoara, Calea Aradului 119, Timis, 300645, Romania
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, 1110939, Chile
Department of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu, 44600, Nepal
Laboratory of Biotechnology, Faculty of Science and Technology, University of Macau, 999078, China
University of Chinese Academy of Sciences, Beijing, 100049, China
State Key Laboratory of Environmental Aquatic Chemistry” with “State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan
SINA Health, Education and Welfare Trust, Karachi, Pakistan
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Faculty of Medicine, University of Porto, Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Gandra PRD, 4585-116, Portugal
TOXRUN-Oxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, Gandra, 4585-116, Portugal
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Chemical and BioChemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai, 400019, India
Victor Babes University of Medicine and Pharmacy of Timisoara Department of Microbiology, Timisoara, Romania
Preventive Medicine Study Center, Timisoara, Romania
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Serdang, 43400 UPM, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Serdang, 43400 UPM, Malaysia
Department of Biochemistry, Bayero University Kano, Kano, Nigeria
Department of Pharmacology, Federal University Dutse, Jigawa State, Dutse, Nigeria
Chemistry & Biochemistry Discipline
Facultad de Ciencias de la Salud
Department of Natural Products Research
Laboratory of Biotechnology
University of Chinese Academy of Sciences
State Key Laboratory of Environmental Aquatic Chemistry” with “State Key Laboratory of Environmental Aquatic Chemistry
Facultad de Medicina
Department of Eastern Medicine
SINA Health
Faculty of Chemistry and Chemical Technology
Faculty of Medicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU)
TOXRUN-Oxicology Research Unit
Department of Nutrition and Dietetics
Universidad de Concepción
Chemical and BioChemical Processing Division
Victor Babes University of Medicine and Pharmacy of Timisoara Department of Microbiology
Preventive Medicine Study Center
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Pharmacology
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