BIOACTIVE COMPOUNDS POTENTIATION AND ANTIBACTERIAL ACTIVITIES OF A PETALONIA FASCIA EXTRACT ON METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS
Alghazeer R. Azwai S. Alksaik M. Elghmasi S. Sidati M. Fituri A.E. Eldaghayes I. Althaluti E. Abomies E.A. Eskandrani A.A. Shamlan G. Alansari W.S. AL-Farga A. Hleba L. Rebezov M. Yermukhametova Z.
2024Slovak University of Agriculture
Journal of Microbiology, Biotechnology and Food Sciences
2024#14Issue 3
The bioactive algal components that contribute to their antimicrobial properties have garnered significant attention, particularly in light of the rising incidence of antibiotic resistance. The current study aimed to evaluate the antibacterial activity of a Petalonia fascia methanolic extract and to explore the potentiation action of extract–antibiotic combinations with the available antibiotics, as well as the effects of their mixture on multidrug-resistant (MDR) bacteria, namely, five methicillin-resistant Staphylococcus aureus (MRSA) strains. The algal crude extract displayed antibacterial activity against all assayed isolates, with an inhibition zone ranging from 16 to 21 mm and the best spectrum of bactericidal effect with a ratio of MBC/MIC < 4 obtained on the five tested bacterial strains. Amoxicillin–extract mixtures decreased the bacterial growth rate dramatically on all five S. aureus isolates in a time-dependent manner. These results indicate the ability of the extract to modulate antibiotic activity. However, the possibility of its use to solve the issue of antibiotic-resistant bacterial strains and their application as therapeutic agents against infectious diseases warrants further investigation.
Antibiotic potentiation activity , MDA , Petalonia fascia , Staphylococcus aureus
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Biochemistry division, Chemistry Department, Faculty of Sciences, University of Tripoli, Tripoli, 50676, Libya
Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Department of Botany, Faculty of Sciences, University of Tripoli, Tripoli, Libya
Department of Biochemistry, Faculty of Medicine, University of Tripoli, Tripoli, Libya
Marin Biotechnology Department, Marin Biology Research Center, Tajura-East of Tripoli, Tripoli, Libya
Department of Marine Chemistry and Physics, Marin Biology Research Center, Tajura-East of Tripoli, Tripoli, Libya
Chemistry Department, Faculty of Science, Taibah University, Medina, 30002, Saudi Arabia
Department of Food Science and Nutrition, College of Food and agriculture Sciences, King Saud University, Riyadh, 11362, Saudi Arabia
Biochemistry Department, Faculty of Science, University of Jeddah, Jeddah, 21577, Saudi Arabia
Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, Nitra, 94976, Slovakia
Department of Scientific Research, Gorbatov Research Center for Food Systems, 26 Talalikhin Str., Moscow, 109316, Russian Federation
Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht str., Yekaterinburg, 620000, Russian Federation
Faculty of Agricultural Sciences, Toraighyrov University, 64 Lomov Str., Pavlodar, 140002, Kazakhstan
Biochemistry division
Department of Microbiology and Parasitology
Department of Botany
Department of Biochemistry
Marin Biotechnology Department
Department of Marine Chemistry and Physics
Chemistry Department
Department of Food Science and Nutrition
Biochemistry Department
Institute of Biotechnology
Department of Scientific Research
Faculty of Biotechnology and Food Engineering
Faculty of Agricultural Sciences
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