Three new monoterpenes compounds isolated from Seriphidium terrae-albae exerted anti-inflammatory effects through the JAK/STAT and NF-κB signaling pathways
Zhu Z. Turak A. Xu N. Jenis J. Aisa H.A.
January 2025Elsevier B.V.
Fitoterapia
2025#180
Three new monoterpenes compounds (5S, 8S)-5-(2E-butenyl)-8-methyl propionate-cyclopentanone (1), 1-Oxy, 10–keto-α-myrcene hydroxide (2), (3R,4R)-3-hydroxy-4-isobutenyl-cyclopentyl ester (3), along with eleven known small molecular compounds such as monoterpenes (1–7, 14), coumarin (10), and other small molecular compounds (8, 9, 11–13) were isolated from Seriphidium terrae-albae. The structures were elucidated by NMR, HRESIMS, ECD calculations, and X-ray crystallography. Anti-inflammatory activity test results showed that 9 compounds were detected to inhibit NO secretion by mouse macrophage Raw 264.7. Among them, the IC50 value of compound 1 (9.56 ± 0.66 μM) was relatively close to the positive control drug Andrographolide (AG) (2.70 ± 0.39 μM). Molecular docking predicted that the target of compound 1 may be the STAT3 proteins. Further mechanism studies have revealed that compound 1 acted on the STAT3 target in the JAK/STAT signaling pathway, indicating the activation of M2 macrophages, exerted anti-inflammatory effects. Additionally, it could also reduce the cytoplasmic NF-κB content achieve the anti-inflammatory effect. Therefore, compound 1 has the potential to become an anti-inflammatory lead compound. This study provides reference value for the research and development of small-molecule natural product anti-inflammatory drugs.
Anti-inflammatory , JAK/STAT , NF-κB , Seriphidium terrae-albae , Small molecular compounds
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State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China
College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China
The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty, 050040, Kazakhstan
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization
College of Pharmacy
The Research Center for Medicinal Plants
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