Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method
Zhautikova S.B. Abdykhanova N.N. Fedorishin D.A. Shapovalova Y.G. Khlebnikov A.I. Bakibaev A.A. Kurzina I.A. Kabieva S.K. Boranbay N. Zhumanazarova G.M.
May 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 10
In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at a level above 50%. At the same time, cucurbit[n]urils (n = 6, 7, 8) do not cause pro-inflammatory activation of monocytic macrophages. The absence of stimulation of pro-inflammatory cytokine expression demonstrates the promising biocompatibility of the studied compounds, which is crucial for their successful clinical use. The obtained results of molecular modeling show the possibility of formation of CB[6], CB[7], and CB[8] associates with various Toll-like receptors, which also confirms good prospects for the development of new ways of medical application of cucurbit[n]urils.
cucurbit[6]uril , cucurbit[7]uril , cucurbit[8]uril , cytotoxicity , immunotoxicity , molecular docking , monocytes , Toll-like receptors
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Karaganda Medical University, Karaganda, 100900, Kazakhstan
Karaganda Industrial University, Temirtau, 101400, Kazakhstan
Department of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk, 634050, Russian Federation
National Research Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
Karaganda Medical University
Karaganda Industrial University
Department of Natural Compounds
National Research Tomsk Polytechnic University
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