Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico
Zainul R. Satriawan H. Novel D.S. Verawati R. Lubis A.P. Jakhmola V. Rebezov M. Syafrizal S. Ahmed S. Lakshmi M.
May 2024Sami Publishing Company
Journal of Applied Organometallic Chemistry
2024#4Issue 288 - 99 pp.
Serotonin analgesics from banana (Musa paradisiaca) fruit have been investigated to determine potential interactions with serotonin 1 b (5-HT1b) receptors at the molecular level. The study utilized an in silico approach to predict the interaction between serotonin analgesics and receptor proteins. The research method involved the use of Pymol, MOE 2015, Discovery Studio, and Lipinski Rule software. The use of Pymol and MOE was used for visualization of the molecular structures of serotonin analgesics and receptor proteins. Discovery Studio was used to analyze the interaction between serotonin analgesic and receptor protein, which revealed the presence of binding between the two with Binding Affinity of-5.1297 and-11.1061 and RMSD of 1.7373 and 3.7057. In addition, analysis by Lipinski Rule revealed the molecular characteristics of the serotonin analgesic, including a mass of 196, no hydrogen bond donor, two hydrogen bond acceptors, a log P of 3.023, and a molar reactivity of 56.390. These results demonstrate the analgesic potential of serotonin in interacting with serotonin 1 b (5-HT1b) receptors, which may form the basis for further research in drug development related to serotonin-based pain treatment.
Banana fruit (Musa paradisiaca) , In silico approach , Molecular interaction , Serotonin 1 b (5-HT1b) receptor protein , Serotonin analgesic
Text of the article Перейти на текст статьи
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, West Sumatra, Padang, Indonesia
Center for Advanced Material Processing, Artificial Intelligence and Biophysics Informatics (CAMPBIOTICS), Universitas Negeri Padang, Indonesia
Institute of Ocean and Earth Sciences, University of Malaya, Kuala Lumpur, 50603, Malaysia
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str, Moscow, 109316, Russian Federation
Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht str, Yekaterinburg, 620075, Russian Federation
Department of Animal Husbandry, Faculty of Agricultural, Universitas Tamansiswa Padang, Indonesia
Department of Biological Sciences, Faculty of Allied Health Sciences, Faculty of Allied Health Sciences, The Superior University, Lahore, Pakistan
International School of Asfendiyarov, Kazakh National Medical University, Almaty, Kazakhstan
Department of Chemistry
Center for Advanced Material Processing
Institute of Ocean and Earth Sciences
Uttaranchal Institute of Pharmaceutical Sciences
Department of Scientific Research
Faculty of Biotechnology and Food Engineering
Department of Animal Husbandry
Department of Biological Sciences
International School of Asfendiyarov
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026