Isolation, biological activity, and synthesis of isoquinoline alkaloids
Yang X. Miao X. Dai L. Guo X. Jenis J. Zhang J. Shang X.
2 October 2024Royal Society of Chemistry
Natural Product Reports
2024#41Issue 111652 - 1722 pp.
Covering: 2019 to 2023 Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014-2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019-2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.
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Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Gansu Province, Lanzhou, 730050, China
China-Kazakh Joint Research Center for Natural Veterinary Drug, Lanzhou, 730050, China
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China
Tibetan Medicine Research Center of Qinghai University, Qinghai University Tibetan Medical College, Qinghai University, Xining, 810016, China
The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Key Laboratory of Veterinary Pharmaceutical Development
China-Kazakh Joint Research Center for Natural Veterinary Drug
College of Veterinary Medicine
Tibetan Medicine Research Center of Qinghai University
The Research Center for Medicinal Plants
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