Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan
Turebekov N. Abdiyeva K. Yegemberdiyeva R. Kuznetsov A. Dmitrovskiy A. Yeraliyeva L. Shapiyeva Z. Batyrbayeva D. Tukhanova N. Shin A. Musralina L. Hoelscher M. Froeschl G. Dobler G. Freimueller K. Wagner E. Frey S. Essbauer S.
June 2021American Society of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene
2021#104Issue 62000 - 2008 pp.
Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific and clinical investigations related to undifferentiated febrile illness and rickettsial diseases in Kazakhstan are lacking. This study reflects the investigation of antibodies against spotted fever group (SFG) and typhus group (TG) rickettsiae in patients with undifferentiated febrile illness in the southern region of Kazakhstan (Almaty and Kyzylorda oblasts). Paired serum samples were gathered from 13 hospitals in these two oblasts and explored for the presence of IgM and IgG antibodies against typhus group and IgG antibodies against spotted fever group rickettsiae using ELISA. Patient’s questionnaires were statistically analyzed. In total, 802 inpatients from Almaty (N = 9) and Kyzylorda (N = 4) hospitals were included in this research. Based on ELISA results, 250 patients out of 802 (31.2%) from both oblasts had IgG antibodies against SFG rickettsiae. Results from 11 (1.4%) patients indicated acute infection with tick-borne rickettsiosis. Regarding TG rickettsiae (R. typhi), a past infection was detected in 248 (30.9%) febrile patients and acute infection in 22 (2.7%) patients in the two selected oblasts. The data indicated that SFG and TG rickettsioses are present in Kazakhstan. Kazakh physicians should be aware of these emerging diseases in both investigated oblasts because the occurrence of these diseases is not suspected during day-to-day clinical practice. The identification of rickettsial pathogens and implementation of modern laboratory methods for the diagnostics of rickettsioses are in need throughout Kazakhstan. Copyright
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Central Reference Laboratory, National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan
Department of Infectious and Tropical Diseases, Kazakh National Medical University, Almaty, Kazakhstan
National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan
Department of Children’s Infectious Diseases, Kazakh National Medical University, Almaty, Kazakhstan
Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Almaty, Kazakhstan
Scientific Clinical Diagnostic Laboratory, Kazakh National Medical University, Almaty, Kazakhstan
Center for International Health, Ludwig-Maximilians-Universität, Munich, Germany
Al-Farabi Kazakh National University, Almaty, Kazakhstan
Institute of General Genetics and Cytology, Almaty, Kazakhstan
Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität, German Center for Infection Research, Munich Partner site, Munich, Germany
Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany
Bundeswehr Research Institute for Protective Technologies and CBRN Protection, Munster, Germany
Central Reference Laboratory
Department of Infectious and Tropical Diseases
National Scientific Center for Especially Dangerous Infections
Department of Children’s Infectious Diseases
Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring
Scientific Clinical Diagnostic Laboratory
Center for International Health
Al-Farabi Kazakh National University
Institute of General Genetics and Cytology
Division of Infectious Diseases and Tropical Medicine
Bundeswehr Institute of Microbiology
Bundeswehr Research Institute for Protective Technologies and CBRN Protection
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