PURSLANE (PORTULACA OLERACEA L.) GROWING IN SOUTH KAZAKHSTAN-PHYTOCHEMICAL COMPOSITION OF ULTRASONIC HYDROETHANOLIC EXTRACT AND ITS PHARMACOLOGICAL ACTIVITY
Tleubayeva M.I. Datkhayev U.M. Malm A. Józefczyk A. Wojtanowski K. Seitaliyeva A.M. Jumagaziyeva A.B. Sakipova Z.B. Kozhanova K.K. Raganina K.T. Zhumabek D.N.
2025Romanian Society for Pharmaceutical Sciences
Farmacia
2025#73Issue 3665 - 675 pp.
Aerial parts of Portulaca oleracea L. growing in South Kazakhstan were subjected to ultrasonic extraction with 70% ethanol. The phytochemical composition of the extract was studied using the RP-HPLC/PDA and HPLC-ESI-QTOF-MS methods. The following extract activities were studied in vivo after its oral administration: acute toxicity in outbred white mice, as well as analgesic activity by the formalin test method and anti-inflammatory effect by the carrageenan oedema method in outbred white rats. A total of 19 compounds were identified in the extract by HPLC-ESI-QTOF-MS fingerprinting, mainly organic acids and their derivatives, and phenolic acid derivatives. According to RP-HPLC/PDA data, the main compounds of this extract were derivatives of ferulic and protocatechuic acids (2.502 mg/100 g d. m.). No signs of extract toxicity and mortality were observed, even at a dose of 2000 mg d. m./kg. The extract at doses of 100 mg d. m./kg and 200 mg d. m./kg exerted a significant reduction in the number of pain reactions in both early and late phases, as well as a marked anti-inflammatory effect. These in vivo data demonstrated, for the first time, an analgesic and anti-inflammatory effect following oral administration of ultrasonic hydroethanolic extract from Kazakh species of purslane.
analgesic effect , anti-inflammatory activity , folk medicine , in vivo studies , Kazakh flora , purslane
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School of Pharmacy, S.D. Asfendiyarov Kazakh National Мedical University, Almaty, Kazakhstan
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland
Department of Pharmacognosy with Medicinal Plants Garden, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland
Department of Fundamental Medicine, Faculty of Medicine and Health, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Microbiology Laboratory, JSC Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan
School of Pharmacy
Department of Pharmaceutical Microbiology
Department of Pharmacognosy with Medicinal Plants Garden
Department of Fundamental Medicine
Microbiology Laboratory
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