Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health-Promoting Abilities
Sharifi-Rad J. Quispe C. Herrera-Bravo J. Belén L.H. Kaur R. Kregiel D. Uprety Y. Beyatli A. Yeskaliyeva B. Kirkin C. Özçelik B. Sen S. Acharya K. Sharopov F. Cruz-Martins N. Kumar M. Razis A.F.A. Sunusi U. Kamal R.M. Shaheen S. Suleria H.A.R.
2021Hindawi Limited
Oxidative Medicine and Cellular Longevity
2021#2021
The Glycyrrhiza genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammatory, antiproliferative, and cytotoxic activities. The species Glycyrrhiza glabra L. and the compound glycyrrhizin (glycyrrhizic acid) have been studied immensely for their effect on humans. The efficacy of the compound has been reported to be significantly higher on viral hepatitis and immune deficiency syndrome. This review provides up-to-date data on the most widely investigated Glycyrrhiza species for food and medicinal purposes, with special emphasis on secondary metabolites composition and bioactive effects.
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Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de la Frontera, Temuco, 4811230, Chile
Department of Chemical Engineering, Universidad de la Frontera, Av. Francisco Salazar 01145, Box 54D, Temuco, Chile
Louis Riel School Division, Winnipeg, R2M 3R3, MB, Canada
Lodz University of Technology, Faculty of Biotechnology and Food Sciences, Wolczanska 171/173, Lodz, 90-924, Poland
Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, P.O. Box 1030, Kirtipur, Kathmandu, Nepal
University of Health Sciences, Department of Medicinal and Aromatic Plants, Istanbul, 34668, Turkey
Al-Farabi Kazakh National University, Faculty of Chemistry and Chemical Technology, Almaty, 050040, Kazakhstan
Department of Gastronomy and Culinary Arts, School of Applied Sciences, Ozyegin University, Cekmekoy, Istanbul, 34794, Turkey
Department Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul, 34469, Turkey
BIOACTIVE Research and Innovation Food Manufacturing Industry Trade Ltd. Co., Maslak, Istanbul, 34469, Turkey
Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, 700019, India
Department of Botany, Fakir Chand College, West Bengal, Diamond Harbour, 743331, India
Research Institution Chinese-Tajik Innovation Center for Natural Products, National Academy of Sciences of the Republic of Tajikistan, Ayni St. 299/2, Dushanbe, 734063, Tajikistan
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, 4200-135, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies, CESPU, Rua Central de Gandra 1317, PRD, Gandra, 4585-116, Portugal
Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai, 400019, India
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia (UPM), Selangor, Serdang, 43400, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia (UPM), Selangor, Serdang, 43400, Malaysia
Department of Biochemistry, Bayero University Kano, PMB 3011, Kano, Nigeria
Department of Pharmacology, Federal University, PMB 7156, Jigawa State, Dutse, Nigeria
Department of Plant Sciences, LCWU, Lahore, 54000, Pakistan
Department of Agriculture and Food Systems, University of Melbourne, Melbourne, 3010, Australia
Phytochemistry Research Center
Facultad de Ciencias de la Salud
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Department of Chemical Engineering
Louis Riel School Division
Lodz University of Technology
Research Centre for Applied Science and Technology (RECAST)
University of Health Sciences
Al-Farabi Kazakh National University
Department of Gastronomy and Culinary Arts
Department Food Engineering
BIOACTIVE Research and Innovation Food Manufacturing Industry Trade Ltd. Co.
Molecular and Applied Mycology and Plant Pathology Laboratory
Department of Botany
Research Institution Chinese-Tajik Innovation Center for Natural Products
Faculty of Medicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies
Chemical and Biochemical Processing Division
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Pharmacology
Department of Plant Sciences
Department of Agriculture and Food Systems
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