Neuroprotective and anti-epileptic potentials of genus Artemisia L.
Sailike B. Omarova Z. Jenis J. Adilbayev A. Akbay B. Askarova S. Jin W.-L. Tokay T.
19 October 2022Frontiers Media S.A.
Frontiers in Pharmacology
2022#13
The Genus Artemisia L. is one of the largest genera in the Asteraceae family growing wild over in Europe, North America, and Central Asia and has been widely used in folk medicine for the treatment of various ailments. Phytochemical and psychopharmacological studies indicated that the genus Artemisia extracts contain various antioxidant and anti-inflammatory compounds and possess antioxidant, anti-inflammatory, antimicrobial, antimalarial, and antitumor activity. Recently, increasing experimental studies demonstrated that many Artemisia extracts offer a great antiepileptic potential, which was attributed to their bioactive components via various mechanisms of action. However, detailed literature on the antiepileptic properties of the genus Artemisia and its mechanism of action is segregated. In this review, we tried to gather the detailed neuroprotective and antiepileptic properties of the genus Artemisia and its possible underlying mechanisms. In this respect, 63 articles were identified in the PubMed and Google scholars databases, from which 18 studies were examined based on the pharmacological use of the genus Artemisia species in epilepsy. The genus Artemisia extracts have been reported to possess antioxidant, anti-inflammatory, neurotransmitter-modulating, anti-apoptotic, anticonvulsant, and pro-cognitive properties by modulating oxidative stress caused by mitochondrial ROS production and an imbalance of antioxidant enzymes, by protecting mitochondrial membrane potential required for ATP production, by upregulating GABA-A receptor and nACh receptor activities, and by interfering with various anti-inflammatory and anti-apoptotic signaling pathways, such as mitochondrial apoptosis pathway, ERK/CREB/Bcl-2 pathway and Nrf2 pathway. This review provides detailed information about some species of the genus Artemisia as potential antiepileptic agents. Hence, we recommend further investigations on the purification and identification of the most biological effective compounds of Artemisia and the mechanisms of their action to cure epilepsy and other neurological diseases. Copyright
cognitive impairment , epilepsy , excitotoxicity , genus artemisia , neuroinflammation , neuroprotection , oxidative stress
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Biology Department, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan
Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan
Laboratory of Bioengineering and Regenerative Medicine, National Laboratory of Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College, Lanzhou University, Lanzhou, China
Biology Department
Research Center for Medicinal Plants
Department of Biomedical Sciences
Laboratory of Bioengineering and Regenerative Medicine
Institute of Cancer Neuroscience
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