α-Carboxylate Phosphabetains in Alkylation and Complexation Reactions
α-КАРБОКСИЛАТНЫЕ ФОСФАБЕТАИНЫ В РЕАКЦИЯХ АЛКИЛИРОВАНИЯ И КОМПЛЕКСООБРАЗОВАНИЯ
Romanov S.R. Shibaeva K.O. Minnullin R.R. Shulaeva M.P. Pozdeev O.K. Tapalova A.S. Galkina I.V. Bakhtiyarova Yu.V.
2023Kazan Federal University
Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki
2023#165Issue 1158 - 169 pp.
Alkylation reactions of α-carboxylate phosphabetaines were carried out and studied to enhance the biological activity of previously synthesized carboxylate phosphabetaines. As a result of these reactions, the original structure was destroyed with the formation of quaternary salts of phosphonium triiodide. The structure and composition were confirmed by a complex of physical research methods, including NMR, IR spectroscopy, and elemental analysis. The bactericidal and antimycotic activity of the synthesized salts was assessed. The compounds showed activity similar to that of commercial drugs. The reactions of complexation of these structures were also investigated. In the reactions with nickel and copper chloride, complexes were isolated and characterized. The structure of the nickel complex was unambiguously confirmed by the data obtained with the help of single-crystal X-ray diffraction analysis.
alkylation , antimicrobial activity , glyoxylic acid , methyl iodide , phosphabetaine , tertiary phosphine
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Kazan Federal University, Kazan, 420008, Russian Federation
Kazan State Medical Academy, Kazan, 420012, Russian Federation
Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
Kazan Federal University
Kazan State Medical Academy
Korkyt Ata Kyzylorda University
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