Targeted Cancer Therapy: Leveraging Dual pH-Sensitive Polymers Nanoparticles for Doxorubicin Delivery and Tumor Suppression: A Review

Rakhimberdiyeva Z. Ganievich M.T. Nurushev M. Baxretdinovna G.M. Rashidov A. Rustamovich A.T. Kenjaevich B.B. Maratovna D.K. Utkurovna N.D. Rasulovna R.M. Ildusovich А.I. Abduqayumovna E.Z. Normakhmat P.
2024 University of Kashan

Journal of Nanostructures
2024 #14 Issue 1 204 - 213 pp.

The global burden of cancer continues to strengthen, using the want for innovative treatment methods that beautify efficacy while minimizing adverse effects. traditional chemotherapies, including the extensively used doxorubicin, face considerable demanding situations consisting of off-target toxicity, poor selectivity, and multidrug resistance (MDR). targeted drug shipping systems have emerged as a progressive solution, with dual pH-touchy polymer nanoparticles gaining significant attention. those structures exploit the acidic tumor microenvironment (TME) to enable selective and managed drug launch, improving healing consequences and lowering systemic toxicity. This overview examines the design, synthesis, and capability of dual pH-sensitive polymer systems, their mechanisms of motion, and preclinical validation. moreover, the potential of those nanoparticles to deal with the limitations of DOX remedy is highlighted, paving the way for their integration into clinical practice. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Cancer , DOX , Polymeric Nanomaterials , Targeted therapies

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Shymkent university, Mukhtar Auezov South Kazakhstan University, Shymkent, Kazakhstan
Faculty of Uzbek and Russian Philology, Kokand State Pedagogical Institute, Uzbekistan
Astana International University, Astana, Kazakhstan
Tashkent State Technical University, Uzbekistan
Department of Theory of the Russian Language and Literature, Kokand State Pedagogical Institute, Uzbekistan
Faculty of Agriculture, Fergana State University, Uzbekistan
Department of therapeutic subjects, Tashkent State Dental Institute, Uzbekistan
Department of Oncology, Center for the Development of Qualifications of Medical Workers, Tashkent, Uzbekistan
Department Clinic Pharmacology, Bukhara State Medical Institute, Uzbekistan
Department of Agronomy, Navoi State Mining and Technological University, Navoi, Uzbekistan
Andijan State medical institute, Uzbekistan
Termez State University, Termez, 190111, Uzbekistan

Shymkent university
Faculty of Uzbek and Russian Philology
Astana International University
Tashkent State Technical University
Department of Theory of the Russian Language and Literature
Faculty of Agriculture
Department of therapeutic subjects
Department of Oncology
Department Clinic Pharmacology
Department of Agronomy
Andijan State medical institute
Termez State University

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