Biological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixture
Rafikova K. Meriç N. Binbay N.E. Okumuş V. Sever M.Ş. Belyankova Y. Tursynbek S. Dauletbakov A. Sarah B. Zolotareva D. Yerassyl K. Dündar A. Güzel R. Aydemir M.
5 May 2024Elsevier B.V.
Journal of Molecular Structure
2024#1303
Synthesis of two phosphinite ligands based on β-amino alcohols, in high yields has been demonstrated. When we treated [Ru(arene)(μ-Cl)Cl]2 {arene:p-cymene,benzene} with chelating phosphinite ligands, we obtained neutral Ru(II)-complexes possessing the general formula [Ru(arene)phosphiniteCl2]. The structure of the ligands and complexes was confirmed using analytical and spectroscopic techniques. The quantum chemical calculations were carried out for the ruthenium complexes at the DFT/CAM-B3LYP level of theory in gas phase. The phosphinite complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). In the present study, the antioxidant potentials of ruthenium-based p-cymene and benzene complexes through DPPH radical scavenging, metal chelating, and reducing power activities were also determined. In addition, DNA binding abilities and antimicrobial activities of these complexes against pathogenic bacteria were studied. Finally, the ruthenium complex, (2S)-1-{[(2S)-2-[(diphenylphosphanyl)oxy]propyl][(1R)-1-phenylethyl]amino}propan-2-yldiphenyl phosphinitobis[dichloro(η6-benzene)ruthenium(II)] also catalyzed asymmetric transfer hydrogenation of acetophenone with high conversion (up to 99%) and good enantioselectivity (ee up to 89 %), in the existence of formic acid and triethylamine in dichloromethane medium under air atmosphere.
Asymmetric transfer hydrogenation (ATH) , Biological assay , CA and OCPA , DFT and CAM-B3LYP , Electrochemical properties , Β-amino alcohols
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Institute of Chemical and Biological Technologies, Satbayev University, Almaty, Kazakhstan
School of Chemical Engineering, Kazakh-British Technical University, Almaty, Kazakhstan
Faculty of Science, Department of Chemistry, Dicle University, Diyarbakir, TR-21280, Turkey
Department of Hair Care and Beauty Services, Technical Vocational School, Dicle University, Diyarbakir, 21280, Turkey
Department of Electronics, Technical Vocational School, Dicle University, Diyarbakir, 21280, Turkey
Faculty of Medicine, Department of Medical Biology, Siirt University, Siirt, 56100, Turkey
Instution of Science, Department of Biology, Siirt University, Siirt, 56100, Turkey
Vocational School of Health Services, Department of Medical Services and Techniques, Mardin Artuklu University, Mardin, 47420, Turkey
Faculty of Education, Department of Science, Dicle University, Diyarbakir, 21280, Turkey
Institute of Chemical and Biological Technologies
School of Chemical Engineering
Faculty of Science
Department of Hair Care and Beauty Services
Department of Electronics
Faculty of Medicine
Instution of Science
Vocational School of Health Services
Faculty of Education
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