Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan
Nurtazina A. Voitsekhovskiy I. Kanapiyanov B. Toishimanov M. Dautov D. Karibayev K. Smail Y. Kozhakhmetova D. Dyussupov A.
October 2024Multidisciplinary Digital Publishing Institute (MDPI)
Journal of Personalized Medicine
2024#14Issue 10
Background: The high global prevalence of prediabetes requires its early identification. Amino acids (AAs) have emerged as potential predictors of prediabetes. This study investigates the association between amino acids and prediabetes in the Kazakh population. Materials and Methods: In this case-control study, serum AAs levels were measured using the Trace GC 1310 gas chromatography system coupled with the TSQ 8000 triple quadrupole mass spectrometer (Thermo Scientific, Austin, TX, USA) followed by silylation with the BSTFA + 1% TMCS derivatization method. Biochemical parameters, including total cholesterol, HDL-C, LDL-C, triglycerides, fasting glucose, HbA1c, and Creatinine, were assessed for each participant. Trained professionals conducted anthropometric and physical examinations (which included taking blood pressure and heart rate measurements) and family history collection. Results: A total of 112 Kazakh individuals with prediabetes and 55 without prediabetes, aged 36–65 years, were included in the study. Only Alanine and valine showed a significant association with prediabetes risk among the 13 AAs analyzed. Our findings revealed an inverse relationship between Alanine and Valine and prediabetes in individuals of Kazakh ethnicity. Conclusion: A lower serum level of Alanine and Valine may serve as a predictive biomarker for prediabetes in the Kazakh population.
alanine , amino acids , Kazakh population , prediabetes , prediction , valine
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Department of Epidemiology and Biostatistics, Semey Medical University, Semey, 071400, Kazakhstan
Outpatient Clinic #1, Department of Internal Medicine and Cardiology, Semey Medical University, Semey, 071400, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, 050038, Kazakhstan
Department of Propaedeutics of Internal Diseases, Semey Medical University, Semey, 071400, Kazakhstan
Food and Environment Safety Laboratory, Kazakstan-Japan Innovative Center, Kazakh National Agrarian Research University, Almaty, 050010, Kazakhstan
Department of Propaedeutics of Internal Diseases, Asfendiyarov Kazakh National Medical University, Almaty, 050012, Kazakhstan
Central Clinical Hospital, Almaty, 050040, Kazakhstan
Department of Infectious Diseases, Dermatology and Immunology, Semey Medical University, Semey, 071400, Kazakhstan
Department of Internal Diseases, Semey Medical University, Semey, 071400, Kazakhstan
Rector Office, Semey Medical University, Semey, 071400, Kazakhstan
Department of Epidemiology and Biostatistics
Outpatient Clinic #1
Faculty of Biology and Biotechnology
Department of Propaedeutics of Internal Diseases
Food and Environment Safety Laboratory
Department of Propaedeutics of Internal Diseases
Central Clinical Hospital
Department of Infectious Diseases
Department of Internal Diseases
Rector Office
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