Synthesis, structure and biological activity of hydrazones derived from 2- and 4-hydroxybenzoic acid hydrazides
Nurkenov O.A. Fazylov S.D. Satpaeva Z.B. Seilkhanov T.M. Turdybekov D.M. Mendibayeva A.Z. Akhmetova S.B. Shulgau Z.T. Alkhimova L.E. Kulakov I.V.
December 2023Elsevier B.V.
Chemical Data Collections
2023#48
The condensation reaction of 4- and 2-hydroxybenzoic acid hydrazides with substituted benzaldehydes led to the formation of a series of hydrazones. The synthesis of hydrazones was carried out successfully in good yields. The structure of compounds was proved by spectral methods. The crystal structures of the methanol solvate of the (E)-N’-[4-(diethylamino)-benzylidene]-4-hydroxybenzohydrazide and the crystalline hydrate of the (E)-N’-[(2‑hydroxy-4-diethylamino)-benzylidene]-4-hydroxybenzohydrazide were described with attention to conformational features and hydrogen bonding. The antimicrobial and antiradical activity of hydrazones was studied using molecular docking and in vitro assays.
Antimicrobial activity , Benzaldehydes , Hydrazides of 2- and 4-hydroxybenzoic acids , Hydrazones , X-ray diffraction analysis
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Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda, 100008, Kazakhstan
Karaganda Industrial University, 30 Republic Ave., Temirtau, 101400, Kazakhstan
Karaganda Buketov University, 28 University St., Karaganda, 100028, Kazakhstan
Ualikhanov University, 76 Abaya St., Kokshetau, 020000, Kazakhstan
Karaganda Medical University, 40 Gogol St., Karaganda, 100000, Kazakhstan
National Center for Biotechnology, 13/5 Kurgalzhynskoe Road, Astana, 010000, Kazakhstan
Center for Nature-Inspired Engineering, University of Tyumen, 15a Perekopskaya St., Tyumen, 625003, Russian Federation
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Karaganda Industrial University
Karaganda Buketov University
Ualikhanov University
Karaganda Medical University
National Center for Biotechnology
Center for Nature-Inspired Engineering
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