Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides
Nurkenov O.A. Fazylov S.D. Nurmaganbetov Z.S. Seilkhanov T.M. Mendibayeva A.Zh. Kabieva S.K. Satbaeva E.M.
22 October 2024Institute of Combustion Problems, al-Farabi Kazakh State National University
Eurasian Chemico-Technological Journal
2024#26Issue 3169 - 174 pp.
The article presents the results of a study of the amination reaction of nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in the search and creation of drugs for respiratory and circulatory stimulants. The study was conducted to search for new biologically active compounds with anti-inflammatory activity. The synthesis of new aminoamides was carried out by the interaction of nicotinic acid with molecules of morpholine, cytisine, and adamantane in anhydrous ethanol. As a result of the conducted studies, new amides of nicotinic acid with high yields (90.7–93.1%) were obtained. The structures of the new compounds were determined using NMR1H and13C spectroscopy methods, as well as data from two-dimensional spectra of COSY (1H-1H), HMQC (1H-13C), HMBC (1H-13C) and mass spectrometry. The results of an experimental study of the anti-inflammatory activity of synthesized new amides are presented. The anti-inflammatory effect of nicotinic acid N-adamantylamide was established, other new amides were ineffective compared with ibuprofen (p2 < 0.05).
1-adamantane , Antiflammatory activity , Chloranhydride , Cytisine , Morpholine , Nicotinic acid , NMR spectroscopy
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Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str, Karaganda, Kazakhstan
Karaganda Industrial University, 30 Republic Ave, Temirtau, Kazakhstan
Sh, Ualikhanov Kokshetau University, 76 Abay str, Kokshetau, Kazakhstan
Asfendiyarov Kazakh National Medical University, 94 Tole bi str, Almaty, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Karaganda Industrial University
Sh
Asfendiyarov Kazakh National Medical University
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