Reaction of o-Formylbenzoic Acid with Hydrazides of (Iso)niconitic and Hydroxybenzoic Acids
Nurkenov O.A. Fazylov S.D. Kulakov I.V. Seilkhanov T.M. Mendibayeva A.Z. Syzdykov A.K. Kabieva S.K.
September 2023Pleiades Publishing
Russian Journal of General Chemistry
2023#93Issue 92202 - 2209 pp.
Abstract: The reaction of nicotinic and isonicotinic acid hydrazides with o-formyl benzoic acid in ethanol led to the formation of the corresponding hydrazones. It was found that o-formyl benzoic acid reacted in aldehyde form with hydrazides to form hydrazones. When heated in acetic anhydride, the latter are smoothly cyclized into 3-acetoxyisoindolin-1-ones. Structure of the synthesized compounds was proved by 1H and 13C NMR spectroscopy data. Antiradical and antiviral activity of the synthesized hydrazones and 3-acetoxyisoindolin-1-ones was studied. A compound with a wide spectrum of virus-inhibiting action against strains of the A virus was identified.
(iso)nicotinic acid hydrazides , 3-acetoxyisoindolin-1-ones , antiviral activity , hydrazones , o-formylbenzoic acid
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Institute of Organic Synthesis and Carbon Chemistry of the Republic of Kazakhstan, Karaganda, 110000, Kazakhstan
Karaganda Industrial University, Temirtau, 101400, Kazakhstan
Institute of Chemistry of Tyumen State University, Tyumen, 625003, Russian Federation
Sh. Ualikhanov Kokshetau University, Kokshetau, 020000, Kazakhstan
Institute of Organic Synthesis and Carbon Chemistry of the Republic of Kazakhstan
Karaganda Industrial University
Institute of Chemistry of Tyumen State University
Sh. Ualikhanov Kokshetau University
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