Circular RNA biomarkers in cardiovascular disease
Nozima T. Batyrkhankyzy N.N. Kadham M.J. Abdufattoevna K.A. Khatamov A. Khaydarova P.S. Bakhodir I. Alisherovna R.N. Kuvatovna K.D. Mukhlisa K. Gulchekhra K. Otabek B. Inomjon M.
15 August 2025Elsevier B.V.
Clinica Chimica Acta
2025#576
Despite medical advancements, heart disease continues to be a primary cause of death globally. While early detection and continuous monitoring are essential for better patient outcomes, current biological markers, such as cardiac troponins and BNP, have shortcomings, including their temporary nature and susceptibility to various factors, such as patient age and other medical conditions. This limitation has motivated scientists to identify new biological indicators and treatment targets that better represent the underlying heart disease mechanisms. Circular RNAs (circRNAs) have recently been identified as key regulatory molecules in various illnesses, including cardiac conditions. These unique noncoding RNA molecules feature a closed circular structure that makes them exceptionally stable and resistant to breakdown. Their durability, specific expression patterns in different tissues, and preservation across species make them promising candidates both as disease markers and potential therapeutic tools for heart conditions. The scientific interest in the role of circRNAs in cardiovascular disease has increased significantly, with studies revealing their involvement in controlling genes and disease development. This comprehensive review examines circRNAs in heart disease, covering their formation, functional mechanisms, and potential clinical applications as disease markers. This paper discusses recent scientific discoveries highlighting their value in diagnosis and prognosis, addresses the difficulties in moving these findings into medical practice and explores future possibilities for the use of circRNAs in heart disease diagnosis and treatment.
Biomarkers , Circular RNAs , Clinical Applications , Heart Disease
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Tashkent Pediatric Medical University, Tashkent, Uzbekistan
Non-state Educational Institution, Kazakh-Russian Medical University, Kazakhstan
College of Medical Techniques, Al-Farahidi University, Baghdad, Iraq
Department of Human Resource Management, Samarkand State University Named After Sharof Rashidov, Uzbekistan
Kimyo International University in Tashkent, Shota Rustaveli street 156, Tashkent, 100121, Uzbekistan
Department of Anesthesiology and Resuscitation, Bukhara State Medical Institute, Bukhara, Uzbekistan
Department of Medicine, Faculty of Medicine, Alfraganus University, Uzbekistan
Department of Pediatrics and Neonatology, Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan
Scientific and Practical Center of Immunology, Allergology and Human Genomics at Samarkand State Medical University, Samarkand, Uzbekistan
Western Caspian University, Scientific researcher, Baku, Azerbaijan
Department of Faculty and Hospital Therapy No. 1 and Occupational Pathology, Tashkent Medical Academy, Farabi street 2, Tashkent, Uzbekistan
Department of General Biology and Physiology, Karakalpak State University Named after Berdakh, Nukus, Uzbekistan
Department of Fruits and Vegetables at the Urgench State University, Uzbekistan
Mamun University, Khiva, Uzbekistan
Tashkent Pediatric Medical University
Non-state Educational Institution
College of Medical Techniques
Department of Human Resource Management
Kimyo International University in Tashkent
Department of Anesthesiology and Resuscitation
Department of Medicine
Department of Pediatrics and Neonatology
Scientific and Practical Center of Immunology
Western Caspian University
Department of Faculty and Hospital Therapy No. 1 and Occupational Pathology
Department of General Biology and Physiology
Department of Fruits and Vegetables at the Urgench State University
Mamun University
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