Conjugates of 3,5-Bis(arylidene)-4-piperidone and Sesquiterpene Lactones Have an Antitumor Effect via Resetting the Metabolic Phenotype of Cancer Cells
Neganova M.E. Aleksandrova Y.R. Sharova E.V. Smirnova E.V. Artyushin O.I. Nikolaeva N.S. Semakov A.V. Schagina I.A. Akylbekov N. Kurmanbayev R. Orynbekov D. Brel V.K.
11 June 2024
Molecules (Basel, Switzerland)
2024#29Issue 12
In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This phenomenon, known as the Warburg effect, provides a number of advantages in the survival of neoplastic cells, and its application is considered a potential strategy in the search for antitumor agents. With the aim of developing a promising platform for designing antitumor therapeutics, we synthesized a library of conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones. To gain insight into the determinants of the biological activity of the prepared compounds, we showed that the conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones, which are cytotoxic agents, demonstrate selective activity toward a number of tumor cell lines with glycolysis-inhibiting ability. Moreover, the results of molecular and in silico screening allowed us to identify these compounds as potential inhibitors of the pyruvate kinase M2 oncoprotein, which is the rate-determining enzyme of glycolysis. Thus, the results of our work indicate that the synthesized conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones can be considered a promising platform for designing selective cytotoxic agents against the glycolysis process, which opens new possibilities for researchers involved in the search for antitumor therapeutics among compounds containing piperidone platforms.
3,5-bis(arylidene)-4-piperidone , acetylenes , alantolactone , azides , click chemistry , cytotoxicity , dehydrocostuslactone , glycolysis , sesquiterpene lactones
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Russian Academy of Sciences, Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Chernogolovka, 142432, Russian Federation
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russian Federation
Laboratory of Engineering Profile Physical and Chemical Methods of Analysis, Korkyt Ata Kyzylorda University, Aiteke bi Str. 29A, Kyzylorda, 120014, Kazakhstan
Russian Academy of Sciences
Nesmeyanov Institute of Organoelement Compounds
Laboratory of Engineering Profile Physical and Chemical Methods of Analysis
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