Immune Response in Obesity and Type 2 Diabetes
Narmuratova G. Mukhalyiev Y. Deeney J.T. Narmuratova M. Abdolla N.
2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 111 - 16 pp.
Obesity is a widespread chronic inflammatory disease that can lead to increased health risks and subsequent development of prediabetes and type 2 diabetes. The World Obesity Federation (WOF) predicts that the global number of obese adults will reach 1 billion by 2030. The World Obesity Federation (WOF) identifies Kazakhstan as a high-risk country for obesity. By 2030, obesity rates in Kazakhstan are expected to rise to 25.7% in men, 29% in women, and 9.5% in children aged 5 to 19. Kazakhstans National Center for Public Health has observed a significant increase in overweight and obesity rates, particularly among children. Epidemiological data indicate that boys have a higher obesity rate than girls. Specifically, 23.6% of boys were classified as overweight, including obesity, compared to 17.6% of girls. Recent studies highlight the role of immune cell function in obesity-related inflammation providing a potential new target for treating obesity-linked inflammatory diseases. This review article discusses the role of immune cells in regulating obesity-related diseases, including diabetes.
B cells , cytokines , immune response , inflammation , obesity , T cells , type 2 diabetes
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Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Medicine, Laboratory of Endocrinology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States
Department of Pediatric Infectious Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Laboratory of Molecular Immunology and Immunobiotechnology, M. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan
Department of Biophysics
Department of Medicine
Department of Pediatric Infectious Diseases
Department of Biotechnology
Laboratory of Molecular Immunology and Immunobiotechnology
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