PHYTOCHEMICAL PROFILING AND ANTIOXIDANT PROPERTIES OF AJANIA FASTIGIATA (C. WINKL.) POLJAKOV (ASTERACEAE)
Mamurova A. Kairanova G. Amertayeva G. Akhtayeva N. Beyatli A. Kiyekbayeva L. Iskakova Z. Zhaldybaev K. Zhumalina K.
2025Romanian Society for Pharmaceutical Sciences
Farmacia
2025#73Issue 41038 - 1046 pp.
This study aims to evaluate the phytochemical composition and antioxidant properties of Ajania fastigiata (C. Winkl.) Poljakov, a medicinal plant native to Kazakhstan. For the first time, a comprehensive GC-MS-based phytochemical profiling of this species was conducted, revealing a unique chemical composition. GC-MS analysis identified 26 bioactive compounds in the ethanol extract, with bicyclo[3,1,1]hept-3-en-2-ol, 4,6,6-trimethyl-(30.6%), hexadecanoic acid (11.0%) and 9,12,15-octadecatrienoic acid (10.7%) as the major constituents. The ethanol extract showed the highest total phenolic content (65.7 mg GAE/g) and flavonoid content (7.18 mg QE/g). Antioxidant activity, evaluated through DPPH and FRAP assays, demonstrated significant radical scavenging capacity (79.21% at 1 mg/mL) and reducing power (1.3727 OD at 1 mg/mL), comparable to gallic acid. The essential oil contained camphor, α-pinene and carvacrol. These findings highlight Ajania fastigiata as a promising natural source of antioxidants and support its potential for pharmaceutical and therapeutic applications. Rezumat.
Ajania fastigiata , antioxidant activity , GC-MS , phytochemical profiling
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Department of Biodiversity and Bioresources, al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Medicinal and Aromatic Plants, University of Health Science, Istanbul, Turkey
Pharmaceutical school, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Research Institute of New Chemical Technologies ENU named after L.N. Gumilyov, Astana, Kazakhstan
Kazakh-Russian Medical University in Kazakhstan, Almaty, Kazakhstan
Department of Biodiversity and Bioresources
Department of Medicinal and Aromatic Plants
Pharmaceutical school
Research Institute of New Chemical Technologies ENU named after L.N. Gumilyov
Kazakh-Russian Medical University in Kazakhstan
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