Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.
Kozhantayeva A. Tursynova N. Kolpek A. Aibuldinov Y. Tursynova A. Mashan T. Mukazhanova Z. Ibrayeva M. Zeinuldina A. Nurlybayeva A. Iskakova Z. Tashenov Y.
August 2024Multidisciplinary Digital Publishing Institute (MDPI)
Pharmaceuticals
2024#17Issue 8
The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.
antimicrobials , antioxidant activity , Chamaenerion latifoliumL , FT-IR profile , HPLC-UV-ESI/MS analysis
Text of the article Перейти на текст статьи
Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana, 010000, Kazakhstan
Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana, 010000, Kazakhstan
Department of Chemistry, Graduate School of IT and Natural Sciences, East Kazakhstan University Named after S. Amanzholov, Ust-Kamenogorsk 010008, Kazakhstan
Faculty of Science and Technology, The Caspian University of Technology and Engineering Named after Sh.Yessenov, Aktau, 130000, Kazakhstan
Department of General and Biological Chemistry, NJSC “Astana Medical University”, Astana, 010000, Kazakhstan
Department of Chemistry and Chemical Technology, Faculty of Technology, M.Kh. Dulaty, Taraz Regional University, Taraz, 080000, Kazakhstan
Research Institute of New Chemical Technologies
Department of Chemistry
Department of Chemistry
Faculty of Science and Technology
Department of General and Biological Chemistry
Department of Chemistry and Chemical Technology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026