Isolation, Characterization, and Utilization of Secondary Metabolites from Ehretia acuminata: Bioactive Compounds for Pharmaceutical and Industrial Applications
Kaur A. Singh M.V. Shukla A. Sethi M. Jayaswal P. Singhal P. Kyrbassova E. Altybayeva N. Sharma S. Baigaziyeva G.
June 2025Engineered Science Publisher
ES Food and Agroforestry
2025#20
Ehretia acuminata, a member of the Boraginaceae family, is a wild tree native to Asia, Africa, Australia, and North America, commonly referred to as Koda. The leaves and bark of E. acuminata have a rich history of utilization in traditional Chinese herbal medicine, where they have been employed to address various health concerns, including fever, oral sores, dysentery, and numerous other ailments. Column chromatography was employed to isolate phytoconstituents from this remarkable plant to uncover its pharmacological potential. Notably, the ethyl acetate extract derived from its leaves and the ethanol extract from its bark exhibited the most promising profiles regarding diverse biological activities. The isolated compounds were characterized through a comprehensive analysis involving ultraviolet-visible (UV), infrared (IR) spectroscopy,1H and13C nuclear magnetic resonance (NMR), and mass spectrometry (MS) techniques. The resulting spectral data unequivocally revealed the identities of the compounds as 3,4′,5,7-tetrahydroxyflavone (85mg), 3-Phenylprop-2-enoic acid (65mg), and 4-Hydroxybenzoic acid (62mg). Significantly, these phytoconstituents were isolated from the Ehretia acuminata plant for the first time. Among these compounds, 3,4′,5,7-tetrahydroxyflavone demonstrated outstanding antioxidant and antimicrobial properties, while 3-Phenylprop-2-enoic acid and 4-Hydroxybenzoic acid exhibited substantial potential in the realms of antioxidant, anti-diabetic, and antimicrobial activities. This groundbreaking research underscores the therapeutic potential of Ehretia acuminata, shedding light on its valuable contributions to traditional medicine and modern pharmacology.
4-Hydroxybenzoic acid , Bioactive compounds , Ehretia acuminata , Kaempferol biological activities
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Department of Chemistry, School of Sciences, IFTM University, Uttar Pradesh, Moradabad, 244102, India
School of Applied and Life Sciences, UIT, Uttaranchal University, Uttarakhand, Dehradun, 248007, India
Department of Chemistry, Gurukul Kangri Vishwavidyalaya, Kanya Gurukul Campus, Uttarakhand, Haridwar, 249404, India
(Research & Development) COER University, Uttarakhand, Roorkee, 247667, India
Department of Chemistry, Birla Institute of Technology & Science, Pilani Campus, Rajasthan, Pilani, 333031, India
Dean School of Allied Sciences, Dev Bhoomi Uttarakhand University, Uttarakhand, Dehradun, 248007, India
Department of Biology of the Institute of Natural Sciences, NPJSC, Kazakh Women’s Teacher Training University, A05C9Y7, St. Gogol, 114 k1, Almaty, 05000, Kazakhstan
Faculty of biology and biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Chemistry, GLA University, 17km Stone, NH-19, Mathura-Delhi Road, Chaumuhan, Uttar Pradesh, Bharthia, 281406, India
Department of Technology of bread products and processing industries, Faculty of Food Technology, Almaty Technological University, Tole bi str.100, Almaty, 050012, Kazakhstan
Department of Chemistry
School of Applied and Life Sciences
Department of Chemistry
(Research & Development) COER University
Department of Chemistry
Dean School of Allied Sciences
Department of Biology of the Institute of Natural Sciences
Faculty of biology and biotechnology
Department of Chemistry
Department of Technology of bread products and processing industries
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