Real-time monitoring of fixed-bed adsorption separation of quercetin from gallic acid based on dual-wavelength fiber optic spectrophotometric method
Guo G. Muhammad T. Yang J. Dolkun A. Chen Y. Reheman A. Jenis J.
2026Taylor and Francis Ltd.
Instrumentation Science and Technology
2026#54Issue 2248 - 265 pp.
Monitoring of fixed-bed adsorption processes is crucial for the efficient separation of bioactive compounds. Conventional monitoring techniques, such as flow-injection analysis and in-situ spectrophotometric detection, are effective for measuring the total concentration of a specific class of compounds or the concentration of a single compound. Herein, a simple dual-wavelength fiber-optic sensing technique was developed for the simultaneous measurement of quercetin (QE) and gallic acid (GA) concentrations. The established standard curves for QE and GA show strong linearity (R2 = 0.9922 and R2 = 0.9962) within concentration ranges of 5–50 mg/L and 1–35 mg/L, respectively. This technique was innovatively integrated with the fixed-bed adsorption technique for real-time monitoring of QE and GA during the adsorption process. The experimental conditions for the fixed-bed adsorption system were optimized: the adsorbent was LXT-052 macroporous resins, the adsorption solvent was 10% ethanol, the desorption solvent was 60% ethanol, with feed, washing, and desorption flow rates of 1.0 mL/min, 2.0 mL/min, and 1.5 mL/min, respectively. Under the optimized condition, the separation of QE from GA, along with the simultaneous and accurate determination of both compounds, was successfully achieved. The developed method offers the advantage of real-time monitoring, making it ideal for process monitoring in the fixed-bed adsorptive separation of QE and GA, as well as for the design of such fixed-bed adsorption systems.
Dual-wavelength method , fiber-optic sensing , fixed-bed adsorption , Quercetin , simultaneous detection
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Fujian Key Laboratory of Toxicant and Drug Toxicology, Medical College, Ningde Normal University, Fujian, Ningde, China
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Xinjiang, Urumqi, China
Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Fujian Key Laboratory of Toxicant and Drug Toxicology
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources
Research Center for Medicinal Plants
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