Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media
Godymchuk A. Ilyashenko A. Konyukhov Y. Offor P.O. Baisalova G.
2022AIMS Press
AIMS Materials Science
2022#9Issue 4642 - 652 pp.
Despite high medical and biological potential, the penetration of iron oxide nanoparticles (NPs) into a human body can cause their dissolution with subsequent accumulation of highly toxic iron compounds. The paper describes the agglomeration and dissolution behavior of differently sized α-Fe2O3 NPs in the simplest biological solutions. The average sizes of the initial NPs according to the BET analysis are 12, 32, and 115 nm. Within 30–60 min exposure, the particle size and concentration of iron released into the solutions increases in the suspensions, accompanied by an intensive change of NPs surface charge. After an hour of exposure, the colloidal properties do not change significantly, although the dissolution degree ambiguously fluctuates. It has been shown that the agglomeration of the particles in the simplest pulmonary fluid is lower than in the simplest sweat fluid, compared to the dissolution degree, which is much higher in the pulmonary fluid than in the sweat. The colloidal stability of suspensions reduces with a decrease of NPs’ size, e.g., the average size of particles is 315, 289, and 248 nm, while zeta potential is 2, 9, and 17 mV, respectively for 12, 32, and 115 nm NPs in 3-hour suspensions. It has been found that 24 h dissolution degree of α-Fe2 NPs reaches 2.3% and 0.4%, respectively, in the simplest pulmonary and sweat fluids. The mechanism of dissolution of hematite NPs in the slightly acidic and acidic mediums is proposed.
Agglomeration , Dissolution , Iron oxide nanoparticles , Simplest pulmonary fluid , Simplest sweat fluid
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Department of Material Science, Tomsk Polytechnic University, 30 Lenina avenue, Tomsk, 634050, Russian Federation
Joint-Stock Company “Scientific and Industrial Centre Polyus”, 56V Kirova Avenue, Tomsk, 634050, Russian Federation
Department of Functional Nanosystems and High Temperature Materials, National University of Science and Technology “MISiS”, 4 Leninsky avenue, Moscow, 119049, Russian Federation
Metallurgical and Materials Engineering Department, Africa Centre of Excellence for Sustainable Power and Energy Development (ACE-SPED), University of Nigeria, Nsukka, 410001, Nigeria
Department of Chemistry, L.N. Gumilyov Eurasian National University, 2 Satpayev Street,Astana, 010008, Kazakhstan
Department of Material Science
Joint-Stock Company “Scientific and Industrial Centre Polyus”
Department of Functional Nanosystems and High Temperature Materials
Metallurgical and Materials Engineering Department
Department of Chemistry
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