Chemistry and toxicity of 7-hydroxymitragynine (7-OHMG): an updated review on the oxidized derivative of mitragynine
Ganasan J. Karunakaran T. Marimuthu Y. Rusmadi N.N. Firouz N.S. Jenis J. Kumar U.S.U.
October 2025Springer Science and Business Media B.V.
Phytochemistry Reviews
2025#24Issue 54051 - 4064 pp.
In-depth review of the complex chemistry and toxicity profiles of 7-hydroxymitragynine (7-OHMG), a psychoactive alkaloid and an oxidative derivative of mitragynine found to be present in the extracts of dried kratom leaves (Mitragyna speciosa). The chemistry of 7-OHMG is thoroughly covered in the study, with special attention paid to its importance as one of the primary psychoactive components found in kratom-based products and substances as well as its profound pharmacological and toxicological effects. Key structural and spectral signatures of 7-OHMG are revealed by spectroscopic investigations, which facilitate its identification and quantification in various matrices. The details on in-vitro and in-vivo research used to investigate the toxicity and safety profile of 7-OHMG were revealed in this review.
7-hydroxymitragynine , Mitragyna speciosa , Mitragynine , Toxicity
Text of the article Перейти на текст статьи
Centre for Drug Research, Universiti Sains Malaysia, Penang, 11800 USM, Malaysia
Research Center for Medicinal Plants of Al-Farabi, Kazakh National University, al-Farabi ave.71, Almaty, 050040, Kazakhstan
Centre for Drug Research
Research Center for Medicinal Plants of Al-Farabi
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026