Serum bile acids in cystic fibrosis patients – glycodeoxycholic acid as a potential marker of liver disease
Drzymała-Czyż S. Dziedzic K. Szwengiel A. Krzyżanowska-Jankowska P. Nowak J.K. Nowicka A. Aringazina R. Drzymała S. Kashirskaya N. Walkowiak J.
January 2022Elsevier B.V.
Digestive and Liver Disease
2022#54Issue 1111 - 117 pp.
Background: Cystic fibrosis (CF) and CF-related liver disease can lead to disturbances in bile acid metabolism. Aim: This study determined serum bile acid concentrations in CF to define their usefulness in liver disease assessment. Methods: Primary, secondary and conjugated bile acid levels were measured in three CF groups (25 patients each) exhibiting: liver cirrhosis, other liver disease, no liver disease, and in 25 healthy subjects (HS). Results: Bile acid levels were higher in CF patients than in HS, except for glycodeoxycholic acid (GDCA). However, bile acid concentrations did not differ between patients with cirrhosis and other liver involvement. GDCA and deoxycholic acid (DCA) differentiated CF patients with non-cirrhotic liver disease from those without liver disease (GDCA-AUC: 0.924, 95%CI 0.822–1.000, p<0.001; DCA-AUC: 0.867, 95%CI: 0.731–1.000, p<0.001). Principal component analysis revealed that in CF liver disease was related to GDCA, GGTP activity, severe genotype and pancreatic insufficiency. Conclusions: A CF-specific bile acid profile was defined and shown to relate to liver disease. GDCA differentiates patients with non-cirrhotic liver involvement from those with no detectable liver disease. Hence, GDCA is a candidate for validation as a biomarker of non-cirrhotic progression of liver disease in CF.
Cholic acid , Cystic fibrosis liver disease , Deoxycholic acid , Liver cirrhosis
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Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland
Department of Bromatology, Poznan University of Medical Sciences, Poznań, Poland
Department of Food Science and Nutrition, Institute of Food Technology of Plant Origin, Poznań University of Life Sciences, Poznań, Poland
Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznań, Poland
Department of Internal Diseases No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Genetic Epidemiology (Cystic Fibrosis Group), Research Centre for Medical Genetics, Moscow, Russian Federation
Department of Pediatric Gastroenterology and Metabolic Diseases
Department of Bromatology
Department of Food Science and Nutrition
Department of Pulmonology
Department of Internal Diseases No1
Department of Genetic Epidemiology (Cystic Fibrosis Group)
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