Naturally-Occurring Bioactives in Oral Cancer: Preclinical and Clinical Studies, Bottlenecks and Future Directions
Butnariu M. Quispe C. Sharifi-Ra J. Pons-Fuste E. Lopez-Jorne P. Zam W. Das T. Dey A. Kumar M. Pentea M. Eid A.H. Umbetova A. Chen J.-T.
September 2022IMR Press Limited
Frontiers in Bioscience - Scholar
2022#14Issue 3
Oral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends on cancer stage and location. As a result of the side effects of currently available drugs, there has been an increasing interest in the search for naturally-occurring bioactives for treating all types of cancer, including OC. Thus, this comprehensive review aims to give a holistic view on OC incidence and impact, while highlights the preclinical and clinical studies related to the use of medicinal plants for OC prevention and the recent developments in bioactive synthetic analogs towards OC management. Chemoprophylactic therapies connect the use of natural and/or synthetic molecules to suppress, inhibit or revert the transformation of oral epithelial dysplasia (DOK) into oral squamous cell carcinoma (OSCC). Novel searches have underlined the promising role of plant extracts and phytochemical compounds, such as curcumin, green tea extract, resveratrol, isothiocyanates, lycopene or genistein against this malignancy. However, poor bioavailability and lack of in vivo and clinical studies and complex pharmacokinetic profiles limit their huge potential of application. However, recent nanotechnological and related advances have shown to be promising in improving the bioavailability, absorption and efficacy of such compounds. Copyright:
bioavailability , curcumin , green tea extract , head and neck squamous cell carcinoma , nanotechnology , oral cancer , phytotherapy
Text of the article Перейти на текст статьи
Banats University of Agricultural Sciences and Veterinary Medicine, King Michael i of Romania from Timisoara, Timis, 300645, Romania
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. 1110887, Iquique, Chile
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19858-58962, Iran
Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca-UMU), Clínica Odontológica Universitaria Hospital Morales Meseguer, Adv. Marques de los velez s/n, Murcia, 30008, Spain
Department of Analytical and Food Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, Tartous, 35XQ+C2F, Syrian Arab Republic
Department of Life Sciences, Presidency University, Kolkata, 1212, India
Chemical and Biochemical Processing Division, ICAR - Central Institute for Research on Cotton Technology, Mumbai, 400019, India
Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, 2713, Qatar
Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, 2713, Qatar
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Life Sciences, National University of Kaohsiung, Kaohsiung, 811, Taiwan
Banats University of Agricultural Sciences and Veterinary Medicine
Facultad de Ciencias de la Salud
Phytochemistry Research Center
Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca-UMU)
Department of Analytical and Food Chemistry
Department of Life Sciences
Chemical and Biochemical Processing Division
Department of Basic Medical Sciences
Biomedical and Pharmaceutical Research Unit
Faculty of Chemistry and Chemical Technology
Department of Life Sciences
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026