Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets
Asgharian P. Tazekand A.P. Hosseini K. Forouhandeh H. Ghasemnejad T. Ranjbar M. Hasan M. Kumar M. Beirami S.M. Tarhriz V. Soofiyani S.R. Kozhamzharova L. Sharifi-Rad J. Calina D. Cho W.C.
December 2022BioMed Central Ltd
Cancer Cell International
2022#22Issue 1
Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effects in addition to the high cost. Subsequently, to reduce these side effects, many studies have suggested the use of natural bioactive compounds. Among these, which have recently attracted the attention of many researchers, quercetin has such properties. Quercetin, a plant flavonoid found in fresh fruits, vegetables and citrus fruits, has anti-cancer properties by inhibiting tumor proliferation, invasion, and tumor metastasis. Several studies have demonstrated the anti-cancer mechanism of quercetin, and these mechanisms are controlled through several signalling pathways within the cancer cell. Pathways involved in this process include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. In addition to regulating these pathways, quercetin controls the activity of oncogenic and tumor suppressor ncRNAs. Therefore, in this comprehensive review, we summarized the regulation of these signalling pathways by quercetin. The modulatory role of quercetin in the expression of various miRNAs has also been discussed. Understanding the basic anti-cancer mechanisms of these herbal compounds can help prevent and manage many types of cancer.
Malignant tumors , Molecular targets , Pharmacology , Quercetin , Signalling pathways
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Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Molecular Medicine, Faculty of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Agro Produce Processing Division, ICAR—Central Institute of Agricultural Engineering, Bhopal, 462038, India
Chemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai, 400019, India
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Clinical Research Development Unit of Sina Educational, Research, and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran
Scientific Production and Technical Center Zhalyn, Almaty, А20Х3F6, Kazakhstan
Facultad de Medicina, Universidad del Azuay, Cuenca, 14-008, Ecuador
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Drug Applied Research Center
Department of Pharmacognosy
Department of Biochemistry and Clinical Laboratories
Student Research Committee
Department of Molecular Medicine
Molecular Medicine Research Center
Agro Produce Processing Division
Chemical and Biochemical Processing Division
Department of Biochemistry
Clinical Research Development Unit of Sina Educational
Scientific Production and Technical Center Zhalyn
Facultad de Medicina
Department of Clinical Pharmacy
Department of Clinical Oncology
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