Metabolic syndrome in reproductive age: A cross-sectional study
Aringazina R. Zholdassova N. Berdesheva G. Nurgaliyeva Z. Kurmanalina G. Zhanalina B. Sharlovych Z.
May 2025Research and Clinical Center for Infertitlity
International Journal of Reproductive BioMedicine
2025#23Issue 5383 - 396 pp.
Background: Obesity and metabolic syndrome (MetS), as components of excess body weight, have reached global epidemic levels. Objective: The study aimed to investigate the features of the MetS course in men and women of reproductive age. Materials and Methods: This cross-sectional study was conducted with 140 participants aged between 35 and 49 yr at City Polyclinics No. 1, 3, and 4, Aktobe, Kazakhstan from March 2016–2019. Participants were divided into 2 subgroups based on diagnosis of MetS. The case group (with MetS), and the control group (without MetS) (n = 70/each consisted of 40 women and 30 men). Anthropometric, instrumental, and laboratory methods were used to confirm the diagnosis of MetS and determine its features in both groups. Results: The results showed an increase in the uric acid level in the blood to 431.00 ± 66.37 μmol/L and 5.47 ± 0.90 mol/day in the urine. Dyslipidemia was also noted in the case group of individuals with high-density lipoprotein levels of 1.22 ± 0.27 mmol/L vs. 1.32 ± 0.47 mmol/L in the control group. The testosterone level was 16.4 ± 3.04 nmol/L in the case group and 20.3 ± 5.6 nmol/L in the control. The difference in testosterone level was found to be statistically significant (p < 0.01). Conclusion: The analysis of sex hormone levels did not reveal any stable trends that could be considered diagnostic. That may indicate a correlation with the reproductive age characteristics of the examined individuals (men and women): significant differences between hormone levels were fixed in the case and control groups.
Abdominal obesity , Dyslipidemia , Insulin resistance , Metabolic syndrome , Sex hormones
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Department of Internal Diseases no. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Therapeutic and Orthopedic Dentistry, Khoja Akhmet Yassawi International University, Turkestan, Kazakhstan
Department of General Hygiene, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pharmacology, Kazakhstan-Russian Medical University, Almaty, Kazakhstan
Department of Internal Diseases no. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Surgical and Pediatric Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pedagogy, International University of Applied Sciences in Lomza, Lomza, Poland
Department of Professional and Pedagogical, Special Education, Andragogy and Management, Educational and Research Institute of Pedagogics, Zhytomyr Ivan Franko State University, Zhytomyr, Ukraine
Department of Internal Diseases no. 1
Department of Therapeutic and Orthopedic Dentistry
Department of General Hygiene
Department of Pharmacology
Department of Internal Diseases no. 2
Department of Surgical and Pediatric Dentistry
Department of Pedagogy
Department of Professional and Pedagogical
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