Chemotherapy-Induced Endothelial Dysfunction: a Bibliometric Analysis of Research Trends from 1994 to 2024
Amanova A. Balmagambetova S. Tlegenova Z. Kubenova K. Kurmanalina G. Zholdin B.
2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 524 - 33 pp.
Chemotherapy-induced endothelial damage is a complex phenomenon that contributes to cardiovascular toxicity and cellular injury in cancer patients. This study presents a comprehensive bibliometric analysis of research on chemotherapy-induced endothelial dysfunction, evaluating global publication trends, key contributing countries, institutions, authors, journals, and research themes. Methods. The research uses a descriptive bibliometric approach to gather and analyze data from 3,430 publications indexed in the Web of Science and Scopus databases, covering the years 1994-2024. The bibliometric analysis includes research articles and review papers written in English that explore endothelial dysfunction in chemotherapy patients. Data analysis was performed using RStudio and the Bibliometrix R package, with VOSviewer employed for visualization. Results. Annual publication trends showed fluctuations, peaking in 2005, with continued scientific interest in recent years. The United States led in publication volume (1, 328 articles), followed by China and Japan. High levels of international collaboration were observed, particularly between the United States and European countries. Harvard Medical School and the National Cancer Institute were among the top contributing institutions. Prominent authors included Wang and Kim, while Cancer Research was identified as the most influential journal, underscoring the interdisciplinary relevance of this topic. The analysis also revealed evolving research trends focusing on angiogenesis, VEGF inhibitors, and international collaboration. Conclusions. This analysis underscores the need to integrate vascular toxicity monitoring into cardio-oncology care to improve early detection and patient outcomes. Given the recent introduction of new classes and groups of chemotherapeutic drugs into practice and the growing body of knowledge in this area, a renewed surge of interest in this topic can be anticipated. Further research will support evidence-based guidelines for managing endothelial damage in cancer therapy.
bibliometric analysis , cancer research , chemotherapy , endothelial dysfunction , publication trends , vascular toxicity
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Department of Internal Diseases-2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Clinical Laboratory at University Medical Center, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Internal Diseases-2
Department of Oncology
Clinical Laboratory at University Medical Center
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