Heterocyclic Antidepressants with Antimicrobial and Fungicide Activity
Zolotareva D. Zazybin A. Belyankova Y. Bayazit S. Dauletbakov A. Seilkhanov T. Kemelbekov U. Aydemir M.
March 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 5
In this review, the presence of antimicrobial and fungicidal activity in heterocyclic antidepressants was investigated. The already proven connection between the intestinal microbiome and mental health prompted the idea of whether these drugs disrupt the normal intestinal microflora. In addition, there is a serious problem of increasing resistance of microorganisms to antibiotics. In this article, we found that almost all of the antidepressants considered (except moclobemide, haloperidol, and doxepin) have antimicrobial activity and can suppress the growth of not only pathogenic microorganisms but also the growth of bacteria that directly affect mental health (such as Lactobacillus, Lactococcus, Streptococcus, Enterococcus, and Bifidobacterium).
antibiotic , antimicrobial activity , fungicide activity , gut–brain axis , heterocyclic antidepressants , microbiome
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School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi Str., Almaty, 050000, Kazakhstan
Laboratory of Engineering Profile NMR Spectroscopy, Ualikhanov Kokshetau University, 76 Abay Str., Sh, Kokshetau, 020000, Kazakhstan
South Kazakhstan Medical Academy, 1 Al-Farabi Square, Shymkent, 160019, Kazakhstan
Faculty of Science, Department of Chemistry, Dicle University, Diyarbakır, 21280, Turkey
School of Chemical Engineering
Laboratory of Engineering Profile NMR Spectroscopy
South Kazakhstan Medical Academy
Faculty of Science
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