Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Zimina T.M. Sitkov N.O. Gareev K.G. Fedorov V. Grouzdev D. Koziaeva V. Gao H. Combs S.E. Shevtsov M.
October 2022 MDPI

Biosensors
2022 #12 Issue 10

Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

biogenic magnetic nanoparticles , biosensors , drug delivery , magnetic nanoparticles , magnetosomes , magnetotactic bacteria , oncotheranostics

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Department of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”, Saint Petersburg, 197022, Russian Federation
Laboratory of Biomedical Nanotechnologies, Institute of Cytology of the Russian Academy of Sciences, Saint Petersburg, 194064, Russian Federation
SciBear OU, Tartu mnt 67/1-13b, Kesklinna Linnaosa, Tallinn, 10115, Estonia
Research Center of Biotechnology of the Russian Academy of Sciences, Institute of Bioengineering, Moscow, 119071, Russian Federation
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University of Munich, Munich, 81675, Germany
National Center for Neurosurgery, Nur-Sultan, 010000, Kazakhstan

Department of Micro and Nanoelectronics
Laboratory of Biomedical Nanotechnologies
SciBear OU
Research Center of Biotechnology of the Russian Academy of Sciences
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry
Department of Radiation Oncology
National Center for Neurosurgery

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