Engineering of ovarian tissue for ovarian dysfunctions: A review
Zhylkybekova A. Koshmaganbetova G.K. Rysmakhanov M.S. Abenova N.A. Mussin N.M. Kaliyev A.A. Mahdipour M. Tamadon A.
1 January 2024Wolters Kluwer Medknow Publications
Asian Pacific Journal of Reproduction
2024#13Issue 13 - 11 pp.
This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to infertility, osteoporosis, and cardiovascular disease. Hormone replacement therapy is a common treatment, but it has limitations and risks. The review focuses on two main approaches in tissue engineering: scaffold-based (3D printing, electrospinning, decellularization) and scaffold-free (stem cell transplantation, organoid cultivation). Both approaches show promise in preclinical studies for creating functional ovarian tissue. Challenges include vascularization, innervation, long-term function, and safety. Despite these challenges, tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction.
Estrogen , Female gonads , Reproductive system , Tissue engineering
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Department of Evidence-Based Medicine and Scientific Management, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Surgery and Urology No.2, West Kazakhstan Medical University, Aktobe, Kazakhstan
Department of Surgery and Transplantation, Aktobe Medical Center, Aktobe, Kazakhstan
Department of Internal Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Department for Scientific Work, West-Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Evidence-Based Medicine and Scientific Management
Department of Surgery and Urology No.2
Department of Surgery and Transplantation
Department of Internal Diseases
Stem Cell Research Center
Department of Reproductive Biology
Department for Scientific Work
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