Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application
Zhylkybayeva N. Paliienko K. Topchylo A. Zaderko A. Géloën A. Borisova T. Grishchenko L. Mariychuk R. Skryshevsky V. Mussabek G. Lysenko V.
December 2024Nature Research
Scientific Reports
2024#14Issue 1
Gd3+- free carbon dots (CDs) were synthesized by one-step solvothermal method using urea, citric acid and 3-(trifluoromethyl)aniline as precursors. Additionally, Gd3+-doped CDs were prepared by incorporating gadolinium chloride (Gd3+ ions) into the synthesis. Size selection of the purified CDs was achieved through filter membranes ranging from 3 kDa to 100 kDa. The chemical composition and optical properties of the obtained samples were characterized by Energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), Dynamic Light Scattering (DLS), proton relaxation time measurements, Ultraviolet–visible (UV-vis) and fluorescence spectroscopies. A comparative analysis revealed a strong size-dependent behavior in the optical properties of both Gd3+-doped and Gd3+-free CDs. Furthermore, in vitro tests confirmed the non-cytotoxicity of Gd3+-doped CDs, indicating their potential applicability in biomedicine for magnetic resonance imaging (MRI) and red fluorescence-based cell and tissue imaging.
Carbon dots , Cell toxicity , Fluorescence , Fluorescent cell labelling , Gd3+-doping , Proton relaxation time
Text of the article Перейти на текст статьи
Faculty of Physics and Technology, Al-Farabi Kazakh National University, 71, al-Farabi Ave., Almaty, 050040, Kazakhstan
Institute of Information and Computational Technologies, 125 Pushkin Str., Almaty, 050000, Kazakhstan
Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, 9 Leontovicha Street, Kyiv, 01054, Ukraine
Corporation Science Park, Taras Shevchenko University of Kyiv, 60 Volodymyrska Str., Kyiv, 01033, Ukraine
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 01601, Ukraine
Light Matter Institute, UMR-5306, Claude Bernard University of Lyon/CNRS, Université de Lyon, Villeurbanne Cedex, 69622, France
University of Lyon, UMR Ecologie Microbienne Lyon (LEM), CNRS 5557, INRAE 1418, Université Claude Bernard Lyon 1, VetAgro Sup, Villeurbanne, 69622, France
University of Presov, 17th November str. 1, Presov, 08001, Slovakia
Faculty of Physics and Technology
Institute of Information and Computational Technologies
Palladin Institute of Biochemistry National Academy of Sciences of Ukraine
Corporation Science Park
Taras Shevchenko National University of Kyiv
Light Matter Institute
University of Lyon
University of Presov
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026