Markers of endometrial receptivity: Modern concepts and clinical significance (A literature review)
Эндометрий рецептивтілігінің маркерлері: заманауи түсініктер және клиникалық маңызы (әдебиетке шолу)
Маркеры рецептивности эндометрия: современные представления и клиническое значение (обзор литературы)
Zhylkybayeva I.M. Klyuyev D.A. Ogizbayeva A.V. Omertayeva D.Y. Kamyshansky Y.K.
2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 4
Relevance: The study of endometrial receptivity is fundamental to understanding implantation mechanisms and optimizing assisted reproductive technology (ART) programs. А substantial proportion of in vitro fertilization (IVF) cycle attempts end in failure, and one of the key reasons is the discrepancy between embryo transfer timing and the patient-specific implantation window. Therefore, investigating endometrial receptivity is critical. Identification of specific markers of endometrial receptivity paves the way for personalized medicine, enabling precise timing of embryo transfer and significantly increasing the chances of success. This makes research in this area highly relevant for the future of ART. The study aimed to systematize current data on existing markers of endometrial receptivity, their diagnostic value, and potential clinical applications. Materials and Methods: A literature search was conducted in PubMed, Scopus, Google Scholar, and Web of Science, including original research, systematic reviews, and meta-analyses. Studies assessing molecular, genetic, proteomic, and morphofunctional markers of endometrial receptivity, as well as research on personalized timing of embryo transfer using endometrial receptivity tests, were reviewed. Results: Current evidence indicates that endometrial receptivity is determined by a complex interplay of factors, including gene and cytokine expression, hormonal environment, stromal and epithelial status, and immunological parameters. The most extensively studied markers include Leukemia Inhibitory Factor (LIF), Homeobox A10 (HOXA10), integrins, Interleukin-1 beta (IL-1β), mucins, and genetic panels, including the Endometrial Receptivity Array (ERA). Clinical studies show that individualizing the timing of embryo transfer based on endometrial receptivity assessment can improve ART outcomes in certain patient groups, particularly in cases of recurrent implantation failure (RIF). Conclusion: Endometrial receptivity is a multifactorial condition involving morphological, molecular, and immunological changes; however, no single marker currently serves as a universal predictor of successful implantation. Further large-scale, high-quality studies are needed. The development of reliable biomarkers to detect defects in endometrial receptivity could be a promising tool to increase implantation success rates in ART programs.
assisted reproductive technology (ART) , endometrial receptivity , implantation window , in vitro fertilization (IVF) , recurrent implantation failure (RIF)
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NJSC Karaganda Medical University, Karaganda, Kazakhstan
NJSC Karaganda Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026