Pharmaco-Toxicological Assessment of a New Phytopreparation and its use in Calf Dyspepsia
Zhylgeldiyeva A. Korabayev Y. Baiberekov N. Nussupova S. Janabekova G. Koibagarov K. Uzyntleuov A.
July-August 2025Unique Scientific Publishers
International Journal of Veterinary Science
2025#14Issue 4752 - 762 pp.
The work aimed to create dosage forms (infusion, extracts) from walnut leaves and bark, to experimentally study their toxicity, and use them to treat dyspepsia in calves. The study was based on observation, statistical analysis, and scientific experiments. The experiments were conducted with the division of calves into experimental and control groups. Laboratory tests included hematological and biochemical analysis. The experiments simulated pathological processes in animals in the vivarium of the Kazakh National Agrarian University and farms of Kazakhstan. The effectiveness of the preparation for activating the immune system was confirmed, and the dosage and method of use were determined. Regarding toxicological methods, general and special types of toxicity were used. According to the developed methodology, alcoholic and aqueous extracts and infusion from the medicinal plant collection were produced. The study developed a liquid phytopreparation derived from walnut (Juglans regia L.) containing bioactive compounds such as tannins, flavonoids, and essential micronutrients. The preparation was proven low-toxic (hazard class IV) with no significant adverse effects. Its application significantly reduced recovery time and normalized blood parameters in calves with dyspepsia, improving therapeutic effectiveness by 20–25% and reducing mortality by 30%. The findings offer a sustainable alternative to antibiotics, enhancing the health and safety of newborn calves in livestock farming.
Clinical status , Cumulation , Extract , Medicinal raw materials , Toxicity
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Kazakh National Agrarian Research University, Almaty, 050010, Kazakhstan
Kazakh National Agrarian Research University
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