Immunomodulatory Effects of Plant Extracts from Salvia deserta Schang. and Salvia sclarea L.
Zhussupova A. Zhumaliyeva G. Ogay V. Issabekova A. Ross S.A. Zhusupova G.E.
October 2022MDPI
Plants
2022#11Issue 20
Medicines, their safety, effectiveness and quality are indispensable factors of national security, important on a global scale. The COVID-19 pandemic has once again emphasized the importance of improving the immune response of the body in the face of severe viral infections. Plants from the Salvia L. genus have long been used in traditional medicine for treatment of inflammatory processes, parasitic diseases, bacterial and viral infections. The aim of the current study was to evaluate the immunomodulatory effects of plant extracts LS-1, LS-2 from Salvia deserta Schang. and LS-3, LS-4 from Salvia sclarea L. plants growing in southern Kazakhstan by conventional and ultrasonic-assisted extraction, respectively. The cytotoxic effects of the named sage extracts on neonatal human dermal fibroblasts (HDFn) were evaluated using the MTT assay. Immunomodulatory effects of the studied extracts were compared by examining their influence on pro-inflammatory cytokine secretion and phagocytic activity of murine immune cells. Depending on the physiological state of the innate immune cells, sage extracts LS-2 and LS-3 had either a stimulating effect on inactivated macrophages or suppressed cytokine-producing activity in LPS-activated macrophages. The greatest increase in TNF-α secretion was found after treatment of spleen T lymphocytes with sage extract LS-2, obtained by ultrasonic-assisted extraction.
conventional extraction , immunomodulatory , sage , ultrasonic-assisted extraction
Text of the article Перейти на текст статьи
Department of Molecular Biology and Genetics, NPJSC Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Stem Cell Laboratory, National Center for Biotechnology, Qorghalzhyn Highway 13/5, Astana, 010000, Kazakhstan
School of Pharmacy, University of Mississippi, P.O. Box 1848, 38677, MS, United States
School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, NPJSC Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Department of Molecular Biology and Genetics
Stem Cell Laboratory
School of Pharmacy
School of Pharmacy
Department of Chemistry and Technology of Organic Substances
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026