Klotho: Potential Marker of High Cardiovascular Risk in Patients With Acute Coronary Syndrome and Chronic Kidney Disease

Zhunuspekova A.S. Orekhov A.Y. Mansurova J.A. Chinybaeva A.A. Karazhanova L.K.
June 2025 Springer International Publishing

Bratislava Medical Journal
2025 #126 Issue 6 960 - 966 pp.

Aim: Recently it was established that the deficit of Klotho morphogenetic protein in serum is one of the most likely predictors of cardiovascular mortality. Purpose of the Study: to examine the association of Klotho with adverse prognosis factors in patients with acute non-ST-segment elevation myocardial infarction and chronic kidney disease. Materials and Methods of the Study: The analysis included patients with acute myocardial infarction without ST-segment elevation and chronic kidney disease. Inclusion criteria: AMI without persistent ST-segment elevation that underwent coronary artery stenting after coronary angiography; presence of chronic kidney disease diagnosed as a decrease in glomerular filtration rate less than 60 ml/min/1.73m2. Exclusion criteria: terminal CKD or patients on program hemodialysis, presence of acute kidney injury, cancer, refusal to participate in the study. Results: Initial analysis showed that decreased Klotho levels were common among elderly patients, and among these patients there was more frequent history of myocardial revascularization, as well as a higher risk of adverse events according to the GRACE scale. The association of Klotho level with three cardiovascular complications risk factors—age (β = −9.884 (SD 1.667), p = 0.000), C-reactive protein level (β = −0.661 (SD 0.205), p = 0.002) and troponin (β = −0.07 (SD 0.031), p = 0.026)—was determined by multiple linear regression method. Conclusion: The prospective study demonstrated that Klotho may act as one of the markers of cardiovascular risk in patients with non-ST elevation myocardial infarction and chronic kidney disease. Its independent association with three risk factors of cardiovascular risk – age, C-reactive protein level and troponin was established.

Biomarkers , Kidney failure , Klotho proteins , Myocardial infarction , Risk factors

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Department of Internal Medicine, Semey Medical University, Abay St. 103, Semey, 071400, Kazakhstan
Astana Medical University, Astana, Kazakhstan

Department of Internal Medicine
Astana Medical University

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