Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity
Zhumaliyeva G. Zhussupova A. Zhusupova G.E. Błońska-Sikora E. Cerreto A. Omirbekova N. Zhunusbayeva Z. Gemejiyeva N. Ramazanova M. Wrzosek M. Ross S.A.
December 2023Multidisciplinary Digital Publishing Institute (MDPI)
Biomedicines
2023#11Issue 12
The study of medicinal plants is important, as they are the natural reserve of potent biologically active compounds. With wide use in traditional medicine and the inclusion of several species (as parts and as a whole plant) in pharmacopeia, species from the genus Salvia L. are known for the broad spectrum of their biological activities. Studies suggest that these plants possess antioxidant, anti-inflammatory, antinociceptive, anticancer, antimicrobial, antidiabetic, antiangiogenic, hepatoprotective, cognitive and memory-enhancing effects. Phenolic acids, terpenoids and flavonoids are important phytochemicals, which are primarily responsible for the medicinal activity of Salvia L. This review collects and summarizes currently available data on the pharmacological properties of sage, outlining its principal physiologically active components, and it explores the molecular mechanism of their biological activity. Particular attention was given to the species commonly found in Kazakhstan, especially to Salvia trautvetteri Regel, which is native to this country.
Kazakhstan , physiologically active components , sage species
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Department of Molecular Biology and Genetics, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, NPJSC Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Department of Pharmaceutical Sciences, Collegium Medicum, Jan Kochanowski University, Kielce, 25-406, Poland
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome, 00185, Italy
Institute of Botany and Phytointroduction, 36D/1 Timiryazev Str., Almaty, 050040, Kazakhstan
Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Laboratory of Biochemistry and Clinical Chemistry, the Preclinical Research Center, Medical University of Warsaw, Warsaw, 02-097, Poland
School of Pharmacy, University of Mississippi, P.O. Box 1848, University, 38677, MS, United States
School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Molecular Biology and Genetics
Department of Chemistry and Technology of Organic Substances
Department of Pharmaceutical Sciences
Department of Chemistry and Technology of Drugs
Institute of Botany and Phytointroduction
Department of Biochemistry and Pharmacogenomics
School of Pharmacy
School of Pharmacy
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