The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

Zhumalina A.K. Tusupkaliev B.T. Zharlykasinova M.B. Zhekeyeva B.A. Darzhanova K.B.
February 2022 Springer

Molecular and Cellular Biochemistry
2022 #477 Issue 2 621 - 625 pp.

Intrauterine infections are an urgent problem of modern neonatology. One of the causes of intrauterine infective foetal lesions is physiological immunosuppression. The purpose of this study is to investigate the cytokine status in newborns infected with perinatal infections, depending on their body weight. The study examined 145 newborns. Taking into account their body weight, they were divided into 2 groups: main and secondary. The study was conducted in the immunological laboratory of the Medical Centre of Marat Ospanov West Kazakhstan Medical University in the city of Aktobe, with the determination of the level of IgM and IgG to the herpes simplex virus (HSV) types 1, 2, cytomegalovirus (CMV), and chlamydia using the MULTISKANASCENT analyser with the “Chemo” T system. The main results of this study are the predominance of the anti-inflammatory component in both normal weight and underweight infants, which is evidence of the Th-cell-mediated immune response prevalence. The applied value of this study lies in the possibility of applying its results in practice to obtain effective methods to counteract the occurrence and development of intrauterine infections.

Disease , Intrauterine infection , Microflora disruption , Newborns

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Department of Childhood Diseases No. 1 with Neonatology, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str., Aktobe, 030000, Kazakhstan
Department of Normal and Topographic Anatomy with Operative Surgery, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str., Aktobe, 030000, Kazakhstan

Department of Childhood Diseases No. 1 with Neonatology
Department of Normal and Topographic Anatomy with Operative Surgery

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